Searching Novel Diagnostic Markers and Targets for Therapy of CKD

Overview

Journal Kidney Int Suppl (2011)

Publisher Elsevier

Specialty Nephrology

Date 2015 Aug 28

PMID 26312150

Citations 11

Authors

Panos Kavvadas

Jean-Claude Dussaule

Christos Chatziantoniou

Affiliations

Soon will be listed here.

Abstract

Over the last decade, identification and characterization of novel markers of progression and targets for therapy of chronic kidney disease (CKD) have been challenging for the research community. Several promising candidates have emerged, mainly from experimental models of CKD that are yet to be investigated in clinical studies. The authors identified two candidate genes: , an extracellular matrix protein involved in bone and dental development, and the d (DDR1), a collagen-binding membrane receptor with tyrosine kinase activity. Both genes are inactive in adulthood under normal conditions but have been shown to be highly inducible following injury to glomerular or tubular epithelial cells. The objective of this review is to summarize recent evidence supporting the role of periostin and DDR1 as potential novel biomarkers and therapeutic targets in CKD.

Citing Articles

Periostin in Bronchiolitis Obliterans Syndrome after Lung Transplant.

Yeo H, Kang J, Kim Y, Cho W Int J Mol Sci. 2024; 25(19).

PMID: 39408746 PMC: 11477235. DOI: 10.3390/ijms251910423.

Cancer-associated fibroblast-derived periostin promotes papillary thyroid tumor growth through integrin-FAK-STAT3 signaling.

Jin X, Deng Q, Ye S, Liu S, Fu Y, Liu Y Theranostics. 2024; 14(7):3014-3028.

PMID: 38773979 PMC: 11103496. DOI: 10.7150/thno.94207.

The Effects of Periostin Expression on Fibroid-Like Transition of Myometrial Cells.

Lenis Y, George J, Lind S, Balboula A, Teixeira J, Patterson A Reprod Sci. 2022; 30(5):1616-1624.

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The cannabinoid receptor 1 is involved in renal fibrosis during chronic allograft dysfunction: Proof of concept.

Dao M, Lecru L, Vandermeersch S, Ferreira M, Ferlicot S, Posseme K J Cell Mol Med. 2019; 23(11):7279-7288.

PMID: 31469511 PMC: 6815790. DOI: 10.1111/jcmm.14570.

A novel ultrasound technique to detect early chronic kidney disease.

Hewadikaram D, Bandara M, Pattivedana A, Jayaweera H, Jayananda K, Madhavi W F1000Res. 2019; 7:448.

PMID: 30906523 PMC: 6415322. DOI: 10.12688/f1000research.14221.2.

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