Macrophage Heterogeneity, Phenotypes, and Roles in Renal Fibrosis

Overview

Journal Kidney Int Suppl (2011)

Publisher Elsevier

Specialty Nephrology

Date 2015 Aug 28

PMID 26312145

Citations 27

Authors

Qi Cao

Yiping Wang

David C H Harris

Affiliations

Soon will be listed here.

Abstract

Macrophages (MΦ) are highly heterogeneous cells that exhibit distinct phenotypic and functional characteristics depending on their microenvironment and the disease type and stage. MΦ are distributed throughout normal and diseased kidney tissue, where they have been recognized as key factors in renal fibrosis. Recent studies have identified switch of phenotype and diverse roles for MΦ in several murine models of kidney disease. In this review, we discuss macrophage heterogeneity and their involvement in renal fibrosis.

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