Reorganization of Nuclear Pore Complexes and the Lamina in Late-Stage Parvovirus Infection

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2015 Aug 28

PMID 26311881

Citations 5

Authors

Elina Mantyla

Einari A Niskanen

Teemu O Ihalainen

Maija Vihinen-Ranta

Affiliations

Soon will be listed here.

Abstract

Canine parvovirus (CPV) infection induces reorganization of nuclear structures. Our studies indicated that late-stage infection induces accumulation of nuclear pore complexes (NPCs) and lamin B1 concomitantly with a decrease of lamin A/C levels on the apical side of the nucleus. Newly formed CPV capsids are located in close proximity to NPCs on the apical side. These results suggest that parvoviruses cause apical enrichment of NPCs and reorganization of nuclear lamina, presumably to facilitate the late-stage infection.

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