Variants on 8q24 and Prostate Cancer Risk in Chinese Population: a Meta-analysis

Overview

Journal Int J Clin Exp Med

Specialty General Medicine

Date 2015 Aug 27

PMID 26309507

Citations 3

Authors

Xiao-Qiang Ren

Jian-Guo Zhang

Shi-Yong Xin

Tao Cheng

Liang Li

Wei-Hua Ren

Affiliations

Soon will be listed here.

Abstract

Previous studies have identified 8q24 as an important region to prostate cancer (PCa) susceptibility. The aim of this study was to investigate the role of six genetic variants on 8q24 (rs1447295, A; rs6983267, G; rs6983561, C; rs7837688, T; rs10090154, T and rs16901979, A) on PCa risk in Chinese population. Online electronic databases were searched to retrieve related articles concerning the association between 8q24 variants and PCa risk in men of Chinese population published between 2000 and 2014. Odds ratio (ORs) with its 95% correspondence interval (CI) were employed to assess the strength of association. Total eleven case-control studies were screened out, including 2624 PCa patients and 2438 healthy controls. Our results showed that three risk alleles of rs1447295 A (OR=1.35, 95% CI=1.19-1.53, P<0.00001), rs6983561 C (C vs. A: OR=1.41, 95% CI=1.21-1.63, P<0.00001) and rs10090154 T (T vs. C: OR=1.48, 95% CI=1.22-1.80, P<0.00001) on8q24 were significantly associated with PCa risk in Chinese population. Furthermore, genotypes of rs1447295, AA+AC; rs6983561, CC+AC and CC; rs10090154, TT+TC; and rs16901979, AA were associated with PCa as well (P<0.01). No association was found between rs6983267, rs7837688 and PCa risk. In conclusions, variants including rs1447295, rs6983561, rs10090154 and rs16901979 on 8q24 might be associated with PCa risk in Chinese population, indicating these four variations may contribute risk to this disease. This meta-analysis was the first study to assess the role of 8q24 variants on PCa risk in Chinese population.

Citing Articles

CRISPRi screens reveal a DNA methylation-mediated 3D genome dependent causal mechanism in prostate cancer.

Ahmed M, Soares F, Xia J, Yang Y, Li J, Guo H Nat Commun. 2021; 12(1):1781.

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An exome-wide rare variant analysis of Korean men identifies three novel genes predisposing to prostate cancer.

Oh J, Shivakumar M, Miller J, Verma S, Lee H, Hong S Sci Rep. 2019; 9(1):17173.

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Association between 8q24 Gene Polymorphisms and the Risk of Prostate Cancer: A Systematic Review and Meta-Analysis.

Li R, Qin Z, Tang J, Han P, Xing Q, Wang F J Cancer. 2017; 8(16):3198-3211.

PMID: 29158792 PMC: 5665036. DOI: 10.7150/jca.20456.

References

Chen M, Huang Y, Yang S, Hsu J, Chang Y, Huang W . Common variants at 8q24 are associated with prostate cancer risk in Taiwanese men. Prostate. 2009; 70(5):502-7. DOI: 10.1002/pros.21084. View

Cropp C, Robbins C, Sheng X, Hennis A, Carpten J, Waterman L . 8q24 risk alleles and prostate cancer in African-Barbadian men. Prostate. 2014; 74(16):1579-88. PMC: 4322001. DOI: 10.1002/pros.22871. View

Zhang Y, Yi P, Chen W, Ming J, Zhu B, Li Z . Association between polymorphisms within the susceptibility region 8q24 and breast cancer in a Chinese population. Tumour Biol. 2014; 35(3):2649-54. DOI: 10.1007/s13277-013-1348-0. View

Haiman C, Le Marchand L, Yamamato J, Stram D, Sheng X, Kolonel L . A common genetic risk factor for colorectal and prostate cancer. Nat Genet. 2007; 39(8):954-6. PMC: 2391283. DOI: 10.1038/ng2098. View

Zheng S, Hsing A, Sun J, Chu L, Yu K, Li G . Association of 17 prostate cancer susceptibility loci with prostate cancer risk in Chinese men. Prostate. 2009; 70(4):425-32. PMC: 3078699. DOI: 10.1002/pros.21076. View

Chan J, Li H, Singh O, Mahajan A, Ramasamy S, Subramaniyan K . 8q24 and 17q prostate cancer susceptibility loci in a multiethnic Asian cohort. Urol Oncol. 2012; 31(8):1553-60. DOI: 10.1016/j.urolonc.2012.02.009. View

Zhao C, Liu M, Xu Y, Yang K, Wei D, Shi X . 8q24 rs4242382 polymorphism is a risk factor for prostate cancer among multi-ethnic populations: evidence from clinical detection in China and a meta-analysis. Asian Pac J Cancer Prev. 2014; 15(19):8311-7. DOI: 10.7314/apjcp.2014.15.19.8311. View

Hui J, Xu Y, Yang K, Liu M, Wei D, Zhang Y . Study of genetic variants of 8q21 and 8q24 associated with prostate cancer in Jing-Jin residents in northern China. Clin Lab. 2014; 60(4):645-52. DOI: 10.7754/clin.lab.2013.130624. View

Du M, Yuan T, Schilter K, Dittmar R, Mackinnon A, Huang X . Prostate cancer risk locus at 8q24 as a regulatory hub by physical interactions with multiple genomic loci across the genome. Hum Mol Genet. 2014; 24(1):154-66. PMC: 4262497. DOI: 10.1093/hmg/ddu426. View

10.

Okobia M, Zmuda J, Ferrell R, Patrick A, Bunker C . Chromosome 8q24 variants are associated with prostate cancer risk in a high risk population of African ancestry. Prostate. 2011; 71(10):1054-63. PMC: 4422491. DOI: 10.1002/pros.21320. View

11.

Ahmadiyeh N, Pomerantz M, Grisanzio C, Herman P, Jia L, Almendro V . 8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC. Proc Natl Acad Sci U S A. 2010; 107(21):9742-6. PMC: 2906844. DOI: 10.1073/pnas.0910668107. View

12.

Oskina N, Boyarskikh U, Lazarev A, Petrova V, Ganov D, Tonacheva O . A replication study examining association of rs6983267, rs10090154, and rs1447295 common single nucleotide polymorphisms in 8q24 region with prostate cancer in Siberians. Urol Oncol. 2013; 32(1):37.e7-12. DOI: 10.1016/j.urolonc.2013.02.017. View

13.

Schaid D . The complex genetic epidemiology of prostate cancer. Hum Mol Genet. 2004; 13 Spec No 1:R103-21. DOI: 10.1093/hmg/ddh072. View

14.

Chung S, Nakagawa H, Uemura M, Piao L, Ashikawa K, Hosono N . Association of a novel long non-coding RNA in 8q24 with prostate cancer susceptibility. Cancer Sci. 2010; 102(1):245-52. DOI: 10.1111/j.1349-7006.2010.01737.x. View

15.

Hazelett D, Coetzee S, Coetzee G . A rare variant, which destroys a FoxA1 site at 8q24, is associated with prostate cancer risk. Cell Cycle. 2012; 12(2):379-80. PMC: 3575466. DOI: 10.4161/cc.23201. View

16.

Antczak A, Wokolorczyk D, Kluzniak W, Kashyap A, Jakubowska A, Gronwald J . The variant allele of the rs188140481 polymorphism confers a moderate increase in the risk of prostate cancer in Polish men. Eur J Cancer Prev. 2014; 24(2):122-7. DOI: 10.1097/CEJ.0000000000000079. View

17.

Zhao C, Liu M, Wang J, Xu Y, Wei D, Yang K . Association of 8 loci on chromosome 8q24 with prostate carcinoma risk in northern Chinese men. Asian Pac J Cancer Prev. 2014; 14(11):6733-8. DOI: 10.7314/apjcp.2013.14.11.6733. View

18.

Grin B, Loeb S, Roehl K, Cooper P, Catalona W, Helfand B . A rare 8q24 single nucleotide polymorphism (SNP) predisposes North American men to prostate cancer and possibly more aggressive disease. BJU Int. 2014; 115(1):101-5. PMC: 4268414. DOI: 10.1111/bju.12847. View

19.

Ma G, Gu D, Lv C, Chu H, Xu Z, Tong N . Genetic variant in 8q24 is associated with prognosis for gastric cancer in a Chinese population. J Gastroenterol Hepatol. 2014; 30(4):689-95. DOI: 10.1111/jgh.12801. View

20.

Meyer K, Maia A, OReilly M, Ghoussaini M, Prathalingam R, Porter-Gill P . A functional variant at a prostate cancer predisposition locus at 8q24 is associated with PVT1 expression. PLoS Genet. 2011; 7(7):e1002165. PMC: 3140991. DOI: 10.1371/journal.pgen.1002165. View