MicroRNAs and Chinese Medicinal Herbs: New Possibilities in Cancer Therapy

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2015 Aug 26

PMID 26305257

Citations 31

Authors

Ming Hong

Ning Wang

Hor Yue Tan

Sai-Wah Tsao

Yibin Feng

Affiliations

Soon will be listed here.

Abstract

In recent decades Chinese medicine has been used worldwide as a complementary and alternative medicine to treat cancer. Plenty of studies have shown that microRNAs (miRNAs) play fundamental roles in many pathological processes, including cancer, while the anti-cancer mechanisms of Chinese medicinal herbs targeting miRNAs also have been extensively explored. Our previous studies and those of others on Chinese medicinal herbs and miRNAs in various cancer models have provided a possibility of new cancer therapies, for example, up-regulating the expression of miR-23a may activate the positive regulatory network of p53 and miR-23a involved in the mechanism underlying the anti-tumor effect of berberine in hepatocellular carcinoma (HCC). In this review, we survey the role of Chinese medicinal herbal products in regulating miRNAs in cancer and the use of mediating miRNAs for cancer treatment. In addition, the controversial roles of herb-derived exogenous miRNAs in cancer treatment are also discussed. It is expected that targeting miRNAs would provide a novel therapeutic approach in cancer therapy by improving overall response and survival outcomes in cancer treatment, especially when combined with conventional therapeutics and Chinese medicinal herbal products.

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References

Plaisier C, Pan M, Baliga N . A miRNA-regulatory network explains how dysregulated miRNAs perturb oncogenic processes across diverse cancers. Genome Res. 2012; 22(11):2302-14. PMC: 3483559. DOI: 10.1101/gr.133991.111. View

Liu M, Siu M, Liu S, Yam J, Ngan H, Chan D . Epigenetic silencing of microRNA-199b-5p is associated with acquired chemoresistance via activation of JAG1-Notch1 signaling in ovarian cancer. Oncotarget. 2014; 5(4):944-58. PMC: 4011596. DOI: 10.18632/oncotarget.1458. View

Liu S, Fang Y, Shen H, Xu W, Li H . Berberine sensitizes ovarian cancer cells to cisplatin through miR-21/PDCD4 axis. Acta Biochim Biophys Sin (Shanghai). 2013; 45(9):756-62. DOI: 10.1093/abbs/gmt075. View

Zhu M, Wang N, Tsao S, Yuen M, Feng Y, Wan T . Up-regulation of microRNAs, miR21 and miR23a in human liver cancer cells treated with Coptidis rhizoma aqueous extract. Exp Ther Med. 2012; 2(1):27-32. PMC: 3440660. DOI: 10.3892/etm.2010.164. View

Zhang Y, Song W, Zhang F, Liu W, Dou K . Differentiation-inducing activity of hydroxycamptothecin on cancer stem-like cells derived from hepatocellular carcinoma. Dig Dis Sci. 2011; 56(8):2473-81. DOI: 10.1007/s10620-011-1601-6. View

Zhang L, Hou D, Chen X, Li D, Zhu L, Zhang Y . Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA. Cell Res. 2011; 22(1):107-26. PMC: 3351925. DOI: 10.1038/cr.2011.158. View

Das J, Podder S, Ghosh T . Insights into the miRNA regulations in human disease genes. BMC Genomics. 2014; 15:1010. PMC: 4256923. DOI: 10.1186/1471-2164-15-1010. View

Witwer K, McAlexander M, Queen S, Adams R . Real-time quantitative PCR and droplet digital PCR for plant miRNAs in mammalian blood provide little evidence for general uptake of dietary miRNAs: limited evidence for general uptake of dietary plant xenomiRs. RNA Biol. 2013; 10(7):1080-6. PMC: 3849155. DOI: 10.4161/rna.25246. View

Akbari Moqadam F, Lange-Turenhout E, Aries I, Pieters R, den Boer M . MiR-125b, miR-100 and miR-99a co-regulate vincristine resistance in childhood acute lymphoblastic leukemia. Leuk Res. 2013; 37(10):1315-21. DOI: 10.1016/j.leukres.2013.06.027. View

10.

Chen W, Qiu Y . Ginsenoside Rh2 Targets EGFR by Up-Regulation of miR-491 to Enhance Anti-tumor Activity in Hepatitis B Virus-Related Hepatocellular Carcinoma. Cell Biochem Biophys. 2015; 72(2):325-31. DOI: 10.1007/s12013-014-0456-9. View

11.

Zhu D, Miao K, Zhu Y, Zhu H, Fan L, Liu P . [Detection of miRNA levels in leukemia patients by real-time quantitative PCR]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010; 18(3):757-61. View

12.

Liu P, Liang H, Xia Q, Li P, Kong H, Lei P . Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR-21 regulation of BCL-2 expression. Clin Transl Oncol. 2013; 15(9):741-6. DOI: 10.1007/s12094-012-0999-4. View

13.

Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee J, Lotvall J . Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007; 9(6):654-9. DOI: 10.1038/ncb1596. View

14.

Mackenzie N, Staines K, Zhu D, Genever P, MacRae V . miRNA-221 and miRNA-222 synergistically function to promote vascular calcification. Cell Biochem Funct. 2014; 32(2):209-16. PMC: 4158883. DOI: 10.1002/cbf.3005. View

15.

Li M, Qiao C, Qin L, Zhang J, Ling C . Application of traditional Chinese medicine injection in treatment of primary liver cancer: a review. J Tradit Chin Med. 2013; 32(3):299-307. DOI: 10.1016/s0254-6272(13)60029-1. View

16.

Yang Q, Wang X, Cui J, Wang P, Xiong M, Jia C . Bidirectional regulation of angiogenesis and miR-18a expression by PNS in the mouse model of tumor complicated by myocardial ischemia. BMC Complement Altern Med. 2014; 14:183. PMC: 4060854. DOI: 10.1186/1472-6882-14-183. View

17.

Lewis B, Burge C, Bartel D . Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 2005; 120(1):15-20. DOI: 10.1016/j.cell.2004.12.035. View

18.

Arroyo J, Chevillet J, Kroh E, Ruf I, Pritchard C, Gibson D . Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc Natl Acad Sci U S A. 2011; 108(12):5003-8. PMC: 3064324. DOI: 10.1073/pnas.1019055108. View

19.

Chen X, Ba Y, Ma L, Cai X, Yin Y, Wang K . Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res. 2008; 18(10):997-1006. DOI: 10.1038/cr.2008.282. View

20.

Li W, Wang Q, Su Q, Ma D, An C, Ma L . Honokiol suppresses renal cancer cells' metastasis via dual-blocking epithelial-mesenchymal transition and cancer stem cell properties through modulating miR-141/ZEB2 signaling. Mol Cells. 2014; 37(5):383-8. PMC: 4044309. DOI: 10.14348/molcells.2014.0009. View