Distinctive Expression Pattern of Interleukin-17 Cytokine Family Members in Colorectal Cancer

Overview

Journal Tumour Biol

Publisher Sage Publications

Specialty Oncology

Date 2015 Aug 26

PMID 26304506

Citations 21

Authors

Ahmed Al-Samadi

Shirin Moossavi

Abdelhakim Salem

Masoud Sotoudeh

Sarianna M Tuovinen

Yrjo T Konttinen

Tuula Salo

Faraz Bishehsari

Affiliations

Soon will be listed here.

Abstract

Colorectal cancer (CRC) is one of the most common cancers in both genders. Even though interleukin (IL)-17A was shown to play an important role in intestinal tumourigenesis and CRC, other IL-17 family members were not studied well. We therefore studied the expression of IL-17 cytokine family members in CRC. Ten healthy colons and ten CRC mucosa were immunostained for IL-17B, IL-17C, IL-17E, and IL-17F, and their receptors IL-17RA, IL-17RB, and IL-17RC. Double immunofluorescence staining of the CRC mucosa was done for IL-17B with markers of neutrophils, endothelial cells, macrophages, T cells, mast cells, or fibroblasts. While IL-17B was increased in CRC with a strong presence both in the epithelial and stromal compartments, IL-17C showed different expression depending on the grade of differentiation and IL-17E remained unchanged. In contrast, IL-17F was decreased in CRC compared to healthy control. Colon epithelial cells stained positive for IL-17RA, IL-17RB, and IL-17RC in both healthy control and CRC. Neutrophils were the main source of IL-17B in the stroma. IL-17 family members demonstrated distinct expression patterns in CRC, suggesting a differential role exerted by each member in colon carcinogenesis.

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