Low Expression of MiRNA-224 Predicts Poor Clinical Outcome in Diffuse Large B-cell Lymphoma Treated with R-CHOP
Overview
Affiliations
Objective: To investigate the expression and prognostic value of miR-224 expression in patients with diffuse large B-cell lymphoma (DLBCL) who underwent R-CHOP.
Materials And Methods: RT-PCR was used to determine the relative expression of miR-224, in 258 DLBCL patients and 40 normal lymphoid tissue specimens.
Results: MiR-224 expression in DLBCL patients was significantly down-regulated compared to that in negative controls (p < 0.05). The 5-year progression-free survival and overall survival rates were significantly higher in the high-expression level group compared to the low-expression level group (p < 0.05).
Conclusions: MiR-224 expression level is implicated as a prognostic marker for DLBCL patients treated with R-CHOP.
MicroRNAs implicated in canine diffuse large B-cell lymphoma prognosis.
Elshafie N, Gribskov M, Lichti N, Sayedahmed E, Childress M, Dos Santos A FEBS Open Bio. 2024; 14(11):1899-1913.
PMID: 39218619 PMC: 11532975. DOI: 10.1002/2211-5463.13887.
Hue S, Jin Y, Cheng H, Bin Masroni M, Tang L, Ho Y Cancers (Basel). 2023; 15(2).
PMID: 36672402 PMC: 9856483. DOI: 10.3390/cancers15020453.
circNBPF10/miR-224 Axis Regulates PBX3 to Promote the Malignant Progression of Lung Cancer.
Zhao X, Song X, Zhao Y J Oncol. 2022; 2022:2832920.
PMID: 35342419 PMC: 8947861. DOI: 10.1155/2022/2832920.
Non-Coding RNAs in Diffuse Large B-Cell Lymphoma.
Shi Y, Ding D, Qu R, Tang Y, Hao S Onco Targets Ther. 2020; 13:12097-12112.
PMID: 33262609 PMC: 7699984. DOI: 10.2147/OTT.S281810.
Zhang L, Huang L, Liang H, Zhang R, Chen G, Pang Y Int J Clin Exp Pathol. 2020; 10(9):9970-9989.
PMID: 31966887 PMC: 6965914.