Biodegradable DNA-Brush Block Copolymer Spherical Nucleic Acids Enable Transfection Agent-Free Intracellular Gene Regulation

Overview

Journal Small

Date 2015 Aug 23

PMID 26297167

Citations 19

Authors

Chuan Zhang

Liangliang Hao

Colin M Calabrese

Yu Zhou

Chung Hang J Choi

Hang Xing

Chad A Mirkin

Affiliations

Soon will be listed here.

Abstract

By grafting multiple DNA strands onto one terminus of a polyester chain, a DNA-brush block copolymer that can assemble into micelle structure is constructed. These micelle spherical nucleic acids have a density of nucleic acids that is substantively higher than linear DNA block copolymer structures, which makes them effective cellular transfection and intracellular gene regulation agents.

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