Mesenchymal Stromal Cells and Viral Infection

Overview

Journal Stem Cells Int

Publisher Wiley

Specialty Cell Biology

Date 2015 Aug 22

PMID 26294919

Citations 52

Authors

Maytawan Thanunchai

Suradej Hongeng

Arunee Thitithanyanont

Affiliations

Soon will be listed here.

Abstract

Mesenchymal Stromal Cells (MSCs) are a subset of nonhematopoietic adult stem cells, readily isolated from various tissues and easily culture-expanded ex vivo. Intensive studies of the immune modulation and tissue regeneration over the past few years have demonstrated the great potential of MSCs for the prevention and treatment of steroid-resistant acute graft-versus-host disease (GvHD), immune-related disorders, and viral diseases. In immunocompromised individuals, the immunomodulatory activities of MSCs have raised safety concerns regarding the greater risk of primary viral infection and viral reactivation, which is a major cause of mortality after allogeneic transplantation. Moreover, high susceptibilities of MSCs to viral infections in vitro could reflect the destructive outcomes that might impair the clinical efficacy of MSCs infusion. However, the interplay between MSCs and virus is like a double-edge sword, and it also provides beneficial effects such as allowing the proliferation and function of antiviral specific effector cells instead of suppressing them, serving as an ideal tool for study of viral pathogenesis, and protecting hosts against viral challenge by using the antimicrobial activity. Here, we therefore review favorable and unfavorable consequences of MSCs and virus interaction with the highlight of safety and efficacy for applying MSCs as cell therapy.

Citing Articles

Mesenchymal stem cells and their extracellular vesicle therapy for neurological disorders: traumatic brain injury and beyond.

Yarahmadi A, Dorri Giv M, Hosseininejad R, Rezaie A, Mohammadi N, Afkhami H Front Neurol. 2025; 16:1472679.

PMID: 39974358 PMC: 11835705. DOI: 10.3389/fneur.2025.1472679.

Isolation of porcine circovirus 3 using primary porcine bone marrow-derived cells.

Hayashi S, Katakura F, Moritomo T, Tsutsumi N, Sugiura K, Sato T Virol J. 2024; 21(1):184.

PMID: 39135096 PMC: 11318261. DOI: 10.1186/s12985-024-02463-2.

Mesenchymal stem cells preconditioned with a TLR5 agonist enhanced immunoregulatory effect through M2 macrophage polarization in a murine graft-versus-host disease model.

Gil S, Im K, Kim N, Lee J, Na H, Min G Int J Med Sci. 2024; 21(9):1649-1660.

PMID: 39006841 PMC: 11241100. DOI: 10.7150/ijms.93121.

Mesenchymal stem cell therapy in diabetic foot ulcer: An updated comprehensive review.

Hetta H, Elsaghir A, Sijercic V, Akhtar M, Gad S, Moses A Health Sci Rep. 2024; 7(4):e2036.

PMID: 38650719 PMC: 11033295. DOI: 10.1002/hsr2.2036.

Potential therapeutic effects and nano-based delivery systems of mesenchymal stem cells and their isolated exosomes to alleviate acute respiratory distress syndrome caused by COVID-19.

Ghiasi M, Zarandi P, Dayani A, Salimi A, Shokri E Regen Ther. 2024; 27:319-328.

PMID: 38650667 PMC: 11035022. DOI: 10.1016/j.reth.2024.03.015.

References

Augello A, Kurth T, De Bari C . Mesenchymal stem cells: a perspective from in vitro cultures to in vivo migration and niches. Eur Cell Mater. 2011; 20:121-33. DOI: 10.22203/ecm.v020a11. View

Cheng K, Rai P, Lan X, Plagov A, Malhotra A, Gupta S . Bone-derived mesenchymal stromal cells from HIV transgenic mice exhibit altered proliferation, differentiation capacity and paracrine functions along with impaired therapeutic potential in kidney injury. Exp Cell Res. 2013; 319(14):2266-74. PMC: 3779877. DOI: 10.1016/j.yexcr.2013.06.008. View

Rollin R, Alvarez-Lafuente R, Marco F, Jover J, Hernandez-Garcia C, Rodriguez-Navas C . Human parvovirus B19, varicella zoster virus, and human herpesvirus-6 in mesenchymal stem cells of patients with osteoarthritis: analysis with quantitative real-time polymerase chain reaction. Osteoarthritis Cartilage. 2007; 15(4):475-8. DOI: 10.1016/j.joca.2006.11.007. View

Reinders M, De Fijter J, Roelofs H, Bajema I, de Vries D, Schaapherder A . Autologous bone marrow-derived mesenchymal stromal cells for the treatment of allograft rejection after renal transplantation: results of a phase I study. Stem Cells Transl Med. 2013; 2(2):107-11. PMC: 3659754. DOI: 10.5966/sctm.2012-0114. View

Dander E, Lucchini G, Vinci P, Introna M, Masciocchi F, Perseghin P . Mesenchymal stromal cells for the treatment of graft-versus-host disease: understanding the in vivo biological effect through patient immune monitoring. Leukemia. 2012; 26(7):1681-4. DOI: 10.1038/leu.2011.384. View

Peng L, Xie D, Lin B, Liu J, Zhu H, Xie C . Autologous bone marrow mesenchymal stem cell transplantation in liver failure patients caused by hepatitis B: short-term and long-term outcomes. Hepatology. 2011; 54(3):820-8. DOI: 10.1002/hep.24434. View

Rong Q, Zhang L, Su E, Li J, Liu Z, Huang Z . Bone marrow-derived mesenchymal stem cells are capable of mediating hepatitis B virus infection in injured tissues. J Viral Hepat. 2008; 15(8):607-14. DOI: 10.1111/j.1365-2893.2008.00978.x. View

Meisel R, Zibert A, Laryea M, Gobel U, Daubener W, Dilloo D . Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation. Blood. 2004; 103(12):4619-21. DOI: 10.1182/blood-2003-11-3909. View

Meisel R, Heseler K, Nau J, Schmidt S, Leineweber M, Pudelko S . Cytomegalovirus infection impairs immunosuppressive and antimicrobial effector functions of human multipotent mesenchymal stromal cells. Mediators Inflamm. 2014; 2014:898630. PMC: 3981523. DOI: 10.1155/2014/898630. View

10.

Aggarwal S, Pittenger M . Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood. 2004; 105(4):1815-22. DOI: 10.1182/blood-2004-04-1559. View

11.

Fellig Y, Almogy G, Galun E, Ketzinel-Gilad M . A hepatocellular carcinoma cell line producing mature hepatitis B viral particles. Biochem Biophys Res Commun. 2004; 321(2):269-74. DOI: 10.1016/j.bbrc.2004.06.148. View

12.

Sharma G, Champalal Sharma D, Hwei Fen L, Pathak M, Bethur N, Pendharkar V . Reduction of influenza virus-induced lung inflammation and mortality in animals treated with a phosophodisestrase-4 inhibitor and a selective serotonin reuptake inhibitor. Emerg Microbes Infect. 2015; 2(8):e54. PMC: 3821288. DOI: 10.1038/emi.2013.52. View

13.

Aurich H, Sgodda M, Kaltwasser P, Vetter M, Weise A, Liehr T . Hepatocyte differentiation of mesenchymal stem cells from human adipose tissue in vitro promotes hepatic integration in vivo. Gut. 2008; 58(4):570-81. DOI: 10.1136/gut.2008.154880. View

14.

Liu X, Feng T, Gong T, Shen C, Zhu T, Wu Q . Human Umbilical Cord Mesenchymal Stem Cells Inhibit the Function of Allogeneic Activated Vγ9Vδ2 T Lymphocytes In Vitro. Biomed Res Int. 2015; 2015:317801. PMC: 4423519. DOI: 10.1155/2015/317801. View

15.

Zhong Y, Lin N, Deng M, Zhang F, Tang Z, Xu R . Deficient proliferation of bone marrow-derived mesenchymal stem cells in patients with chronic hepatitis B viral infections and cirrhosis of the liver. Dig Dis Sci. 2009; 55(2):438-45. DOI: 10.1007/s10620-009-0733-4. View

16.

Sundin M, Orvell C, Rasmusson I, Sundberg B, Ringden O, Le Blanc K . Mesenchymal stem cells are susceptible to human herpesviruses, but viral DNA cannot be detected in the healthy seropositive individual. Bone Marrow Transplant. 2006; 37(11):1051-9. DOI: 10.1038/sj.bmt.1705368. View

17.

Malcherek G, Jin N, Huckelhoven A, Mani J, Wang L, Gern U . Mesenchymal stromal cells inhibit proliferation of virus-specific CD8(+) T cells. Leukemia. 2014; 28(12):2388-94. DOI: 10.1038/leu.2014.273. View

18.

Crisan M, Yap S, Casteilla L, Chen C, Corselli M, Park T . A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell. 2008; 3(3):301-13. DOI: 10.1016/j.stem.2008.07.003. View

19.

Hang H, Xia Q . Role of BMSCs in liver regeneration and metastasis after hepatectomy. World J Gastroenterol. 2014; 20(1):126-32. PMC: 3886001. DOI: 10.3748/wjg.v20.i1.126. View

20.

Martinho G, Romanelli R, Teixeira G, Macedo A, Chaia J, Nobre V . Infectious complications associated with the use of central venous catheters in patients undergoing hematopoietic stem cell transplantation. Am J Infect Control. 2013; 41(7):642-4. DOI: 10.1016/j.ajic.2012.10.005. View