Cellular Deficiency in the RGS10 Protein Facilitates Chemoresistant Ovarian Cancer

Overview

Journal Future Med Chem

Specialties Chemistry
Pharmacy

Date 2015 Aug 22

PMID 26293348

Citations 7

Authors

Shelley B Hooks

Mandi M Murph

Affiliations

Soon will be listed here.

Abstract

More than 30 regulators of G protein signaling (RGS) proteins encompass the RGS protein superfamily of critical regulators essential to cellular homeostasis. There is enormous structural and functional diversity among the RGS superfamily, and as such they serve a wide range of functions in regulating cell biology and physiology. Recent evidence has suggested roles for multiple RGS proteins in cancer initiation and progression, which has prompted research toward the potential modulation of these proteins as a new approach in cancer therapy. This article will discuss basic RGS molecular pharmacology, summarize the cellular functions and epigenetic regulation of RGS10, review ovarian cancer chemotherapy and describe the role of RGS10 in ovarian cancer survival signaling.

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