Alpha 2.0

» Articles » PMID: 26291823

Fish-Free Diet in Patients with Phenylketonuria Is Not Associated with Early Atherosclerotic Changes and Enhanced Platelet Activation

Overview

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2015 Aug 21

PMID 26291823

Citations 6

Authors

Authors

Patrik Htun

Jens Nee

Ursula Ploeckinger

Klaus Eder

Tobias Geisler

Meinrad Gawaz

Wolfgang Bocksch

Suzanne Fateh-Moghadam

Affiliations

Affiliations

Soon will be listed here.

Abstract

Background And Purpose: Since patients with phenylketonuria (PKU) have to follow a lifelong restriction of natural protein to lower phenylalanine-intake, they never eat fish. This diet may lead to a chronic deficit of omega-3 and omega-6 fatty acids with the risk of early atherosclerotic changes. The aim of the study was to analyse the fatty acid profile of PKU patients and to correlate the results with surrogate markers of early atherosclerotic changes [enhanced carotid intima media thickness (CIMT) and ß-stiffness index] and platelet activation.

Methods: In 43 PKU patients and in 58 healthy controls we prospectively examined the fatty acid profile, CIMT, ß-stiffness index and platelet activation (flow cytometric determination of markers of platelet activation). CIMT was measured bilaterally by ultrasound. CIMTmean was defined as the mean value of the sum of CIMTleft and CIMTright.

Results: Despite of lower HDL-cholesterol and higher triglyceride concentrations in the PKU group, there was no significant difference in the omega-6 or omega-3 fatty acid profile, CIMT, ß-stiffness index between both groups. Platelet activation was not enhanced in the PKU group.

Conclusions: Fish-free diet does not induce early atherosclerotic changes or enhanced platelet activation in PKU patients.

Citing Articles

Nutrient Status and Intakes of Adults with Phenylketonuria.

Venegas E, Langeveld S, Ahring K, Benitez R, Desloovere A, Dios E Nutrients. 2024; 16(16).

PMID: 39203860 PMC: 11357144. DOI: 10.3390/nu16162724.

Systematic literature review of the somatic comorbidities experienced by adults with phenylketonuria.

Whitehall K, Rose S, Clague G, Ahring K, Bilder D, Harding C Orphanet J Rare Dis. 2024; 19(1):293.

PMID: 39135125 PMC: 11318169. DOI: 10.1186/s13023-024-03203-z.

Morphofunctional Assessment beyond Malnutrition: Fat Mass Assessment in Adult Patients with Phenylketonuria-Systematic Review.

Luengo-Perez L, Fernandez-Bueso M, Guzman-Carmona C, Lopez-Navia A, Garcia-Lobato C Nutrients. 2024; 16(12).

PMID: 38931188 PMC: 11206948. DOI: 10.3390/nu16121833.

The cardiovascular phenotype of adult patients with phenylketonuria.

Azabdaftari A, van der Giet M, Schuchardt M, Hennermann J, Plockinger U, Querfeld U Orphanet J Rare Dis. 2019; 14(1):213.

PMID: 31492166 PMC: 6731621. DOI: 10.1186/s13023-019-1188-0.

Clinical burden of illness in patients with phenylketonuria (PKU) and associated comorbidities - a retrospective study of German health insurance claims data.

Trefz K, Muntau A, Kohlscheen K, Altevers J, Jacob C, Braun S Orphanet J Rare Dis. 2019; 14(1):181.

PMID: 31331350 PMC: 6647060. DOI: 10.1186/s13023-019-1153-y.

References

1.

Conquer J, Cheryk L, Chan E, Gentry P, Holub B . Effect of supplementation with dietary seal oil on selected cardiovascular risk factors and hemostatic variables in healthy male subjects. Thromb Res. 1999; 96(3):239-50. DOI: 10.1016/s0049-3848(99)00106-1. View

2.

Fateh-Moghadam S, Li Z, Ersel S, Reuter T, Htun P, Plockinger U . Platelet degranulation is associated with progression of intima-media thickness of the common carotid artery in patients with diabetes mellitus type 2. Arterioscler Thromb Vasc Biol. 2005; 25(6):1299-303. DOI: 10.1161/01.ATV.0000165699.41301.c5. View

3.

Yuan J, Ross R, Gao Y, Yu M . Fish and shellfish consumption in relation to death from myocardial infarction among men in Shanghai, China. Am J Epidemiol. 2001; 154(9):809-16. DOI: 10.1093/aje/154.9.809. View

4.

Angerer P, Kothny W, Stork S, von Schacky C . Effect of dietary supplementation with omega-3 fatty acids on progression of atherosclerosis in carotid arteries. Cardiovasc Res. 2002; 54(1):183-90. DOI: 10.1016/s0008-6363(02)00229-8. View

5.

Morrison W, Smith L . PREPARATION OF FATTY ACID METHYL ESTERS AND DIMETHYLACETALS FROM LIPIDS WITH BORON FLUORIDE--METHANOL. J Lipid Res. 1964; 5:600-8. View

6.

Chetty N, Bradlow B . The effects of a vegetarian diet on platelet function and fatty acids. Thromb Res. 1983; 30(6):619-24. DOI: 10.1016/0049-3848(83)90270-0. View

7.

Li D, Sinclair A, Mann N, Turner A, Ball M, Kelly F . The association of diet and thrombotic risk factors in healthy male vegetarians and meat-eaters. Eur J Clin Nutr. 1999; 53(8):612-9. DOI: 10.1038/sj.ejcn.1600817. View

8.

Leaf A, Jorgensen M, Jacobs A, Cote G, Schoenfeld D, Scheer J . Do fish oils prevent restenosis after coronary angioplasty?. Circulation. 1994; 90(5):2248-57. DOI: 10.1161/01.cir.90.5.2248. View

9.

Emoto M, Nishizawa Y, Kawagishi T, Maekawa K, Hiura Y, Kanda H . Stiffness indexes beta of the common carotid and femoral arteries are associated with insulin resistance in NIDDM. Diabetes Care. 1998; 21(7):1178-82. DOI: 10.2337/diacare.21.7.1178. View

10.

BANG H, Dyerberg J, Hjoorne N . The composition of food consumed by Greenland Eskimos. Acta Med Scand. 1976; 200(1-2):69-73. DOI: 10.1111/j.0954-6820.1976.tb08198.x. View

11.

. National Institutes of Health Consensus Development Conference Statement: phenylketonuria: screening and management, October 16-18, 2000. Pediatrics. 2001; 108(4):972-82. DOI: 10.1542/peds.108.4.972. View

12.

Myrup B, Rossing P, Jensen T, Parving H, Holmer G, Gram J . Lack of effect of fish oil supplementation on coagulation and transcapillary escape rate of albumin in insulin-dependent diabetic patients with diabetic nephropathy. Scand J Clin Lab Invest. 2001; 61(5):349-56. DOI: 10.1080/003655101316911387. View

13.

Kromhout D, Feskens E, Bowles C . The protective effect of a small amount of fish on coronary heart disease mortality in an elderly population. Int J Epidemiol. 1995; 24(2):340-5. DOI: 10.1093/ije/24.2.340. View

14.

Mezzano D, Munoz X, Martinez C, Cuevas A, Panes O, Aranda E . Vegetarians and cardiovascular risk factors: hemostasis, inflammatory markers and plasma homocysteine. Thromb Haemost. 1999; 81(6):913-7. View

15.

Siscovick D, Raghunathan T, King I, Weinmann S, Wicklund K, Albright J . Dietary intake and cell membrane levels of long-chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest. JAMA. 1995; 274(17):1363-7. DOI: 10.1001/jama.1995.03530170043030. View

16.

Hara A, RADIN N . Lipid extraction of tissues with a low-toxicity solvent. Anal Biochem. 1978; 90(1):420-6. DOI: 10.1016/0003-2697(78)90046-5. View

17.

Oomen C, Feskens E, Rasanen L, Fidanza F, Nissinen A, Menotti A . Fish consumption and coronary heart disease mortality in Finland, Italy, and The Netherlands. Am J Epidemiol. 2000; 151(10):999-1006. DOI: 10.1093/oxfordjournals.aje.a010144. View

18.

Gawaz , Neumann , SCHOMIG . Evaluation of platelet membrane glycoproteins in coronary artery disease : consequences for diagnosis and therapy . Circulation. 1999; 99(1):E1-E11. DOI: 10.1161/01.cir.99.1.e1. View

19.

Moseley K, Koch R, Moser A . Lipid status and long-chain polyunsaturated fatty acid concentrations in adults and adolescents with phenylketonuria on phenylalanine-restricted diet. J Inherit Metab Dis. 2002; 25(1):56-64. DOI: 10.1023/a:1015142001578. View

20.

NELSON G, Schmidt P, Bartolini G, Kelley D, Kyle D . The effect of dietary docosahexaenoic acid on platelet function, platelet fatty acid composition, and blood coagulation in humans. Lipids. 1997; 32(11):1129-36. DOI: 10.1007/s11745-997-0145-6. View