Oxidative Stress in β-thalassaemia and Sickle Cell Disease

Overview

Journal Redox Biol

Specialties Biology
Cell Biology
Endocrinology

Date 2015 Aug 19

PMID 26285072

Citations 69

Authors

S Voskou

M Aslan

P Fanis

M Phylactides

M Kleanthous

Affiliations

Soon will be listed here.

Abstract

Sickle cell disease and β-thalassaemia are inherited haemoglobinopathies resulting in structural and quantitative changes in the β-globin chain. These changes lead to instability of the generated haemoglobin or to globin chain imbalance, which in turn impact the oxidative environment both intracellularly and extracellularly. The ensuing oxidative stress and the inability of the body to adequately overcome it are, to a large extent, responsible for the pathophysiology of these diseases. This article provides an overview of the main players and control mechanisms involved in the establishment of oxidative stress in these haemoglobinopathies.

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