Epigenetic Regulation of Traf2- and Nck-interacting Kinase (TNIK) in Polycystic Ovary Syndrome

Overview

Journal Am J Transl Res

Specialty General Medicine

Date 2015 Aug 18

PMID 26279758

Citations 3

Authors

Da Li

Jiao Jiao

Yi-Ming Zhou

Xiu-Xia Wang

Affiliations

Soon will be listed here.

Abstract

Emerging evidence has led to considerable interest in the role of Traf2- and Nck-interacting kinase (TNIK) in polycystic ovary syndrome (PCOS) development. However, the epigenetic mechanism regulating TNIK transcription remains largely unknown. Here, we show that (i) TNIK mRNA expression is significantly increased in PCOS ovarian tissues, compared to normal ovarian tissues; (ii) PCOS ovarian tissues exhibit a hypermethylation pattern at the cg10180092 site, (iii) and cg10180092 is the critical site for the transcriptional regulation of TNIK. Mechanistically, hypermethylated cg10180092 site-mediated loss of holocarboxylase synthetase (HLCS)-related H3K9me enrichment activated TNIK transcription in PCOS ovarian tissues. Notably, a substantial body of evidence indicates that DNA hypermethylation is an alternative mechanism for gene inactivation, and a new role for DNA hypermethylationmediated TNIK activating was observed in this study. This may improve our understanding of divergent transcriptional regulation in the initiation and progression of TNIK-related PCOS.

Citing Articles

TNIK in disease: from molecular insights to therapeutic prospects.

Wu X, Zhang Z, Qiu Z, Wu X, Chen J, Liu L Apoptosis. 2024; 29(9-10):1361-1376.

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Metabolic and Molecular Mechanisms of Diet and Physical Exercise in the Management of Polycystic Ovarian Syndrome.

Scarfo G, Daniele S, Fusi J, Gesi M, Martini C, Franzoni F Biomedicines. 2022; 10(6).

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Polycystic Ovary Syndrome: the Epigenetics Behind the Disease.

Eiras M, Pinheiro D, Romcy K, Ferriani R, Reis R, Furtado C Reprod Sci. 2021; 29(3):680-694.

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