Zic2 Controls the Migration of Specific Neuronal Populations in the Developing Forebrain

Overview

Journal J Neurosci

Specialty Neurology

Date 2015 Aug 14

PMID 26269635

Citations 18

Authors

Blanca Murillo

Nuria Ruiz-Reig

Macarena Herrera

Alfonso Fairen

Eloisa Herrera

Affiliations

Soon will be listed here.

Abstract

Significance Statement: Although the phenotype of Zic2 mutant individuals was reported more than 10 years ago, until now, the main function of this transcription factor during early development has not been precisely defined. Here, we reveal a previously unknown role for Zic2 in the migration of forebrain neurons such as Cajal-Retzius cells, interneurons moving to the ventral lateral geniculate nucleus, and neocortical cells going to the amygdala. We believe that the role of this transcription factor in certain populations of migratory cells contributes to defects in cortical layering and hypocellularity in the ventral LGN and amygdala and will contribute to our understanding of the devastating phenotypes associated with Zic2 mutations in both humans and mice.

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