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Mesothelioma Treatment: Are We on Target? A Review

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Journal J Adv Res
Date 2015 Aug 11
PMID 26257929
Citations 15
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Abstract

Targeted treatment is a therapy directed at a specific molecular target close to a hallmark of cancer. The target should be measurable with a biomarker and measurement of the target should correlate with clinical outcome when targeted treatment is administered. Current clinical guidelines do not recommend targeted or biological therapy in MPM. However, since these recommendations came out, new agents have been investigated in MPM. This review updates the use of targeted and biological treatment in patients with mesothelioma.

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References
1.
Scherpereel A, Astoul P, Baas P, Berghmans T, Clayson H, De Vuyst P . Guidelines of the European Respiratory Society and the European Society of Thoracic Surgeons for the management of malignant pleural mesothelioma. Eur Respir J. 2009; 35(3):479-95. DOI: 10.1183/09031936.00063109. View

2.
Sekido Y . Genomic abnormalities and signal transduction dysregulation in malignant mesothelioma cells. Cancer Sci. 2009; 101(1):1-6. PMC: 11159396. DOI: 10.1111/j.1349-7006.2009.01336.x. View

3.
Papa S, Popat S, Shah R, Prevost A, Lal R, McLennan B . Phase 2 study of sorafenib in malignant mesothelioma previously treated with platinum-containing chemotherapy. J Thorac Oncol. 2013; 8(6):783-7. DOI: 10.1097/JTO.0b013e31828c2b26. View

4.
Ceresoli G, Zucali P, Mencoboni M, Botta M, Grossi F, Cortinovis D . Phase II study of pemetrexed and carboplatin plus bevacizumab as first-line therapy in malignant pleural mesothelioma. Br J Cancer. 2013; 109(3):552-8. PMC: 3738125. DOI: 10.1038/bjc.2013.368. View

5.
Szlosarek P, Steele J, Nolan L, Gilligan D, Taylor P, Spicer J . Arginine Deprivation With Pegylated Arginine Deiminase in Patients With Argininosuccinate Synthetase 1-Deficient Malignant Pleural Mesothelioma: A Randomized Clinical Trial. JAMA Oncol. 2016; 3(1):58-66. DOI: 10.1001/jamaoncol.2016.3049. View