Chronic Symptoms and Pulmonary Dysfunction in Post-tuberculosis Brazilian Patients

Overview

Journal Braz J Infect Dis

Specialty Infectious Diseases

Date 2015 Aug 10

PMID 26254689

Citations 17

Authors

Simone de Sousa Elias Nihues

Eliane Viana Mancuzo

Nara Sulmonetti

Flavia Patussi Correia Sacchi

Vanessa de Souza Viana

Eduardo Martins Netto

Silvana Spindola Miranda

Julio Croda

Affiliations

Soon will be listed here.

Abstract

Background: Questionnaire and spirometry were applied to post-tuberculosis indigenous and non-indigenous individuals from Dourados, Brazil, to investigate the prevalence of chronic respiratory symptoms and pulmonary dysfunction.

Methods: This was a cross-sectional study in cured tuberculosis individuals as reported in the National System on Reportable Diseases (SINAN) from 2002 to 2012.

Results: One hundred and twenty individuals were included in the study and the prevalence of chronic respiratory symptoms was 45% (95% CI, 34-59%). Respiratory symptoms included cough (28%), sputum (23%), wheezing (22%) and dyspnea (8%). These symptoms were associated with alcoholism, AOR: 3.1 (1.2-8.4); less than 4 years of schooling, AOR: 5.0 (1.4-17.7); and previous pulmonary diseases, AOR: 5.4 (1.7-17.3). Forty-one percent (95% CI, 29-56) had pulmonary disorders, of which the most prevalent were obstructive disorders (49%), followed by obstructive disorder with reduced forced vital capacity disorders (46%) and restrictive disorders (5%). The lifestyle difference could not explain differences in chronic symptoms and/or the prevalence of pulmonary dysfunction.

Conclusion: The high prevalence of chronic respiratory symptoms and pulmonary dysfunction in post-tuberculosis patients indicates a need for further interventions to reduce social vulnerability of patients successfully treated for tuberculosis.

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References

Lee S, Kim Y, Kim D, Oh Y, Lee S . The risk of obstructive lung disease by previous pulmonary tuberculosis in a country with intermediate burden of tuberculosis. J Korean Med Sci. 2011; 26(2):268-73. PMC: 3031013. DOI: 10.3346/jkms.2011.26.2.268. View

Longhi R, Zembrzuski V, Basta P, Croda J . Genetic polymorphism and immune response to tuberculosis in indigenous populations: a brief review. Braz J Infect Dis. 2013; 17(3):363-8. PMC: 9427389. DOI: 10.1016/j.bjid.2012.11.001. View

Correia Sacchi F, Croda M, Estevan A, Ko A, Croda J . Sugar cane manufacturing is associated with tuberculosis in an indigenous population in Brazil. Trans R Soc Trop Med Hyg. 2013; 107(3):152-7. DOI: 10.1093/trstmh/trs089. View

Hijjar M, Gerhardt G, Teixeira G, Procopio M . [Retrospect of tuberculosis control in Brazil]. Rev Saude Publica. 2007; 41 Suppl 1:50-8. DOI: 10.1590/s0034-89102007000800008. View

Ramos L, Sulmonett N, Ferreira C, Henriques J, Miranda S . Functional profile of patients with tuberculosis sequelae in a university hospital. J Bras Pneumol. 2007; 32(1):43-7. DOI: 10.1590/s1806-37132006000100010. View

Basta P, Camacho L . [Tuberculin skin test to estimate the prevalence of Mycobacterium tuberculosis infection in indigenous populations in the Americas: a literature review]. Cad Saude Publica. 2006; 22(2):245-54. DOI: 10.1590/s0102-311x2006000200002. View

Apostu M, Mihaescu T . [Respiratory functional changes in pulmonary tuberculosis]. Pneumologia. 2013; 62(3):148-57. View

Pefura-Yone E, Kengne A, Tagne-Kamdem P, Afane-Ze E . Clinical significance of low forced expiratory flow between 25% and 75% of vital capacity following treated pulmonary tuberculosis: a cross-sectional study. BMJ Open. 2014; 4(7):e005361. PMC: 4120340. DOI: 10.1136/bmjopen-2014-005361. View

Vargha G . Fifteen year follow-up of lung function in obstructive and non-obstructive pulmonary tuberculosis. Acta Med Hung. 1983; 40(4):271-6. View

10.

Ferreira Lemos E, Alves A, Oliveira G, Rodrigues M, Martins N, Croda J . Health-service performance of TB treatment for indigenous and non-indigenous populations in Brazil: a cross-sectional study. BMC Health Serv Res. 2014; 14:237. PMC: 4049501. DOI: 10.1186/1472-6963-14-237. View

11.

Hnizdo E, Singh T, Churchyard G . Chronic pulmonary function impairment caused by initial and recurrent pulmonary tuberculosis following treatment. Thorax. 1999; 55(1):32-8. PMC: 1745584. DOI: 10.1136/thorax.55.1.32. View

12.

Kim H, Song K, Goo J, Lee J, Lee K, Lim T . Thoracic sequelae and complications of tuberculosis. Radiographics. 2001; 21(4):839-58; discussion 859-60. DOI: 10.1148/radiographics.21.4.g01jl06839. View

13.

Cantalice Filho J, Sant Anna C, Boia M . [Clinical aspects of pulmonary tuberculosis in elderly patients from a university hospital in Rio de Janeiro, Brazil]. J Bras Pneumol. 2008; 33(6):699-706. DOI: 10.1590/s1806-37132007000600014. View

14.

Croda M, Trajber Z, Lima R, Croda J . Tuberculosis control in a highly endemic indigenous community in Brazil. Trans R Soc Trop Med Hyg. 2012; 106(4):223-9. DOI: 10.1016/j.trstmh.2012.01.005. View

15.

Di Naso F, Pereira J, Schuh S, Unis G . [Functional evaluation in patients with pulmonary tuberculosis sequelae]. Rev Port Pneumol. 2011; 17(5):216-21. DOI: 10.1016/j.rppneu.2011.06.010. View

16.

Cruz R, de Albuquerque M, Campelo A, E Silva E, Mazza E, Menezes R . [Pulmonary tuberculosis: association between extent of the residual pulmonary lesion and alteration in the lung function]. Rev Assoc Med Bras (1992). 2008; 54(5):406-10. DOI: 10.1590/s0104-42302008000500012. View