Prevalence, Risk Factors, and Health-related Quality of Life of Osteoporosis in Patients with COPD at a Community Hospital in Taiwan

Overview

Journal Int J Chron Obstruct Pulmon Dis

Publisher Dove Medical Press

Specialty Pulmonary Medicine

Date 2015 Aug 8

PMID 26251589

Citations 16

Authors

Chun-Wei Lin

Yih-Yuan Chen

Yi-Jen Chen

Chi-Yen Liang

Ming-Shian Lin

Wei Chen

Affiliations

Soon will be listed here.

Abstract

Background: Data regarding osteoporosis in COPD patients in Taiwan remain limited. The primary end point of this study was to evaluate the prevalence and risk factors of osteoporosis in COPD patients in Taiwan. The secondary end point was to examine the association between osteoporosis and health-related quality of life (HRQL) in COPD patients.

Materials And Methods: This prospective cross-sectional study enrolled 125 COPD patients (mean age 73.6 years, forced expiratory volume in 1 second [FEV1] 1.19±0.43 L) who had bone mineral-density measurements performed consecutively. Demographic data, lung function, and HRQL including modified Medical Research Council dyspnea scale, St George's Respiratory Questionnaire, oxygen-cost diagram, Center for Epidemiologic Studies - depression scale, and COPD Assessment Test scores were recorded.

Results: A total of 50 (40%) participants were diagnosed as having osteoporosis. In a multivariate logistic regression model including age, smoking amount (pack-year), body mass index (BMI), and FEV1, only BMI (odds ratio 0.824, 95% confidence interval 0.73-0.93; P=0.002) and FEV1 (odds ratio 0.360, 95% confidence interval 0.13-0.98; P=0.046) were negatively associated with an increased risk of osteoporosis in COPD patients. In addition, COPD patients with osteoporosis had significantly higher modified Medical Research Council dyspnea scale scores (1.7±0.8 vs 1.4±0.8, P=0.046), St George's Respiratory Questionnaire scores (36.6 vs 28.0, P=0.01), and COPD Assessment Test scores (14.7±8 vs 11.5±7, P=0.019), and lower oxygen-cost diagram score (4.8±1.8 vs 5.4±1.6, P=0.045) than patients without osteoporosis.

Conclusion: The prevalence of osteoporosis in COPD patients was high at a community hospital in Taiwan. BMI and FEV1 were the independent risk factors for osteoporosis in COPD. In addition, COPD patients with osteoporosis had worse HRQL than those without osteoporosis.

Citing Articles

Epidemiology of Osteoporosis in Patients with Chronic Obstructive Pulmonary Disease in Taiwan.

Liao K, Shen C, Chiu K, Lu C, Fang C, Chen C J Epidemiol Glob Health. 2024; 14(1):213-222.

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Low Lung Function Is Associated with Low Baseline Calcaneus Ultrasound T-Score but a Slow Decline in T-Score in a Taiwanese Follow-Up Population with No History of Smoking, Bronchitis, Emphysema, or Asthma.

Tsai Y, Wang H, Wu D, Huang J, Wu P, Chen S J Pers Med. 2023; 13(5).

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Risk factors of osteoporosis in soldiers of the Armed Forces: A cross-sectional study from Western India.

Bandyopadhyay K, Ray S, Shikha D, Bhalla G, Khetan A Med J Armed Forces India. 2023; 79(2):194-200.

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Osteoporosis in COPD patients: Risk factors and pulmonary rehabilitation.

Li Y, Gao H, Zhao L, Wang J Clin Respir J. 2022; 16(7):487-496.

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Treatable Traits in COPD - A Proposed Approach.

Cardoso J, Ferreira A, Guimaraes M, Oliveira A, Simao P, Sucena M Int J Chron Obstruct Pulmon Dis. 2021; 16:3167-3182.

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