Characterization of an Enterobacter Cloacae Strain Producing Both KPC and NDM Carbapenemases by Whole-Genome Sequencing

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2015 Aug 7

PMID 26248381

Citations 25

Authors

Wenjing Wu

Yu Feng

Alessandra Carattoli

Zhiyong Zong

Affiliations

Soon will be listed here.

Abstract

A carbapenem-resistant Enterobacter cloacae strain, WCHECl-14653, causing a fatal bloodstream infection, was characterized by genome sequencing and conjugation experiments. The strain carried two carbapenemase genes, blaNDM-1 and blaKPC-2, on separate IncF plasmids. The coexistence of blaNDM-1 and blaKPC-2 conferred slightly higher-level carbapenem resistance compared with that of blaNDM-1 or blaKPC-2 alone, and the coexistence of two IncF plasmids may generate new platforms for spreading carbapenemase genes.

Citing Articles

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Chimeric systems composed of swapped Tra subunits between distantly-related F plasmids reveal striking plasticity among type IV secretion machines.

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