Applications of Magnetic Resonance Imaging for Treatment-resistant Late-life Depression

Overview

Journal Dialogues Clin Neurosci

Specialty Neurology

Date 2015 Aug 7

PMID 26246790

Citations 5

Authors

Christian Agudelo

Howard J Aizenstein

Jordan F Karp

Charles F Reynolds 3rd

Affiliations

Soon will be listed here.

Abstract

Late-life depression (LLD) is a growing public and global health concern with diverse clinical manifestations and etiology. This literature review summarizes neuroimaging findings associated with depression in older adults and treatment-response variability. LLD has been associated with cerebral atrophy, diminished myelin integrity, and cerebral lesions in frontostriatal-limbic regions. These associations help explain the depression-executive dysfunction syndrome observed in LLD, and support cerebrovascular burden as a pathogenic mechanism. Furthermore, this review suggests that neuroimaging determinants of treatment resistance also reflect cerebrovascular burden. Of the theoretical etiologies of LLD, cerebrovascular burden may mediate treatment resistance. This review proposes that neuroimaging has the potential for clinical translation. Controlled trials may identify neuroimaging biomarkers that may inform treatment by identifying depressed adults likely to remit with pharmacotherapy, identifying individualized therapeutic dose, and facilitating earlier treatment response measures. Neuroimaging also has the potential to similarly inform treatment response variability from treatment with aripiprazole (dopamine modulator) and buprenorphine (opiate modulator).

Citing Articles

A comparative meta-analysis of structural magnetic resonance imaging studies and gene expression profiles revealing the similarities and differences between late life depression and mild cognitive impairment.

Zhao L, Niu L, Dai H, Lee T, Huang R, Zhang R Psychol Med. 2024; :1-10.

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Increasing variance of rich-club nodes distribution in early onset depression according to dynamic network.

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Pathomechanisms of Vascular Depression in Older Adults.

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Forty years of structural brain imaging in mental disorders: is it clinically useful or not?.

Peter F, Andrea S, Nancy A Dialogues Clin Neurosci. 2018; 20(3):179-186.

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Vascular depression consensus report - a critical update.

Aizenstein H, Baskys A, Boldrini M, Butters M, Diniz B, Jaiswal M BMC Med. 2016; 14(1):161.

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