DNA Sequence Variants in the Five Prime Untranslated Region of the Cyclooxygenase-2 Gene Are Commonly Found in Healthy Dogs and Gray Wolves

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2015 Aug 6

PMID 26244515

Citations 1

Authors

Noa Safra

Louisa J Hayward

Miriam Aguilar

Benjamin N Sacks

Jodi L Westropp

F Charles Mohr

Cathryn S Mellersh

Danika L Bannasch

Affiliations

Soon will be listed here.

Abstract

The aim of this study was to investigate the frequency of regional DNA variants upstream to the translation initiation site of the canine Cyclooxygenase-2 (Cox-2) gene in healthy dogs. Cox-2 plays a role in various disease conditions such as acute and chronic inflammation, osteoarthritis and malignancy. A role for Cox-2 DNA variants in genetic predisposition to canine renal dysplasia has been proposed and dog breeders have been encouraged to select against these DNA variants. We sequenced 272-422 bases in 152 dogs unaffected by renal dysplasia and found 19 different haplotypes including 11 genetic variants which had not been described previously. We genotyped 7 gray wolves to ascertain the wildtype variant and found that the wolves we analyzed had predominantly the second most common DNA variant found in dogs. Our results demonstrate an elevated level of regional polymorphism that appears to be a feature of healthy domesticated dogs.

Citing Articles

Correction: DNA Sequence Variants in the Five Prime Untranslated Region of the Cyclooxygenase-2 Gene Are Commonly Found in Healthy Dogs and Gray Wolves.

Safra N, Hayward L, Aguilar M, Sacks B, Westropp J, Mohr F PLoS One. 2018; 13(4):e0195924.

PMID: 29634753 PMC: 5892905. DOI: 10.1371/journal.pone.0195924.

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