Role of Quorum Sensing in Bacterial Infections

Overview

Journal World J Clin Cases

Publisher Baishideng Publishing Group

Specialty General Medicine

Date 2015 Aug 6

PMID 26244150

Citations 77

Authors

Israel Castillo-Juarez

Toshinari Maeda

Edna Ayerim Mandujano-Tinoco

Maria Tomas

Berenice Perez-Eretza

Silvia Julieta Garcia-Contreras

Thomas K Wood

Rodolfo Garcia-Contreras

Affiliations

Soon will be listed here.

Abstract

Quorum sensing (QS) is cell communication that is widely used by bacterial pathogens to coordinate the expression of several collective traits, including the production of multiple virulence factors, biofilm formation, and swarming motility once a population threshold is reached. Several lines of evidence indicate that QS enhances virulence of bacterial pathogens in animal models as well as in human infections; however, its relative importance for bacterial pathogenesis is still incomplete. In this review, we discuss the present evidence from in vitro and in vivo experiments in animal models, as well as from clinical studies, that link QS systems with human infections. We focus on two major QS bacterial models, the opportunistic Gram negative bacteria Pseudomonas aeruginosa and the Gram positive Staphylococcus aureus, which are also two of the main agents responsible of nosocomial and wound infections. In addition, QS communication systems in other bacterial, eukaryotic pathogens, and even immune and cancer cells are also reviewed, and finally, the new approaches proposed to combat bacterial infections by the attenuation of their QS communication systems and virulence are also discussed.

Citing Articles

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Evaluation of HPLC Profile, Antioxidant, Quorum Sensing, Biofilm, Swarming Motility, and Enzyme Inhibition Activities of Conventional and Green Extracts of .

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Li S, Li W, Malhi N, Huang J, Li Q, Zhou Z Molecules. 2024; 29(22).

PMID: 39598860 PMC: 11597810. DOI: 10.3390/molecules29225471.

Design and synthesis of quorum-sensing agonist for improving biofilm formation and the application of in bioleaching.

Tang D, Xi Y, Song W, Li M, Liu Y, Lin Y Front Microbiol. 2024; 15:1465633.

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Prevention and potential remedies for antibiotic resistance: current research and future prospects.

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