Low Serum Alpha-Antitrypsin Associated with Anti-PR-3 ANCA in Autistic Children with GI Disease

Overview

Journal Genomics Insights

Publisher Sage Publications

Date 2015 Aug 6

PMID 26244018

Citations 5

Authors

A J Russo

A Krigsman

B Jepson

Andrew Wakefield

Affiliations

Soon will be listed here.

Abstract

Aim: To assess the possible relationship between serum alpha-1 antitrypsin (AAT) levels and anti-neutrophil cytoplasmic antibodies (ANCA) in autistic children with severe GI disease and to test the hypothesis that there is an association between low serum AAT levels, the presence of ANCA and inflammatory GI disease seen in some autistic children.

Subjects And Methods: Serum from 40 autistic children with chronic digestive disease (many with ileo-colonic lymphoid nodular hyperplasia (LNH) and inflammation of the colorectum, small bowel and/or stomach), and 41 controls (21 age matched autistic children with no GI disease and 20 age matched children without autism or GI disease) were tested using ELISAs designed to quantitate ANCA (anti-PR3), AAT and PR3 levels.

Results: We found that a significant number of autistic children with chronic digestive disease had anti-PR3 ANCA, high serum PR3 and high severity of disease when compared to controls. This same group of autistic children had low serum levels of AAT compared to controls, which also correlated with the presence of anti-PR3 ANCA, high serum PR3, as well as the severity of intestinal disease, particularly LNH and severe erythema.

Discussion: These results suggest a relationship between low AAT levels, ANCA and severity of GI disease seen in a subpopulation of ASD individuals. We suggest that low AAT levels may result in high levels of PR3, which may, in turn be associated with the presence of ANCA.

Citing Articles

Increased Copper in Individuals with Autism Normalizes Post Zinc Therapy More Efficiently in Individuals with Concurrent GI Disease.

Russo A Nutr Metab Insights. 2013; 4:49-54.

PMID: 23946661 PMC: 3738468. DOI: 10.4137/NMI.S6827.

Plasma copper and zinc concentration in individuals with autism correlate with selected symptom severity.

Russo A, Bazin A, Bigega R, Carlson 3rd R, Cole M, Contreras D Nutr Metab Insights. 2013; 5:41-7.

PMID: 23882147 PMC: 3698472. DOI: 10.4137/NMI.S8761.

Analysis of Copper and Zinc Plasma Concentration and the Efficacy of Zinc Therapy in Individuals with Asperger's Syndrome, Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS) and Autism.

Russo A, DeVito R Biomark Insights. 2011; 6:127-33.

PMID: 22174567 PMC: 3235993. DOI: 10.4137/BMI.S7286.

Low serum myeloperoxidase in autistic children with gastrointestinal disease.

Russo A, Krigsman A, Jepson B, Wakefield A Clin Exp Gastroenterol. 2011; 2:85-94.

PMID: 21694831 PMC: 3108639. DOI: 10.2147/ceg.s6051.

Decreased Serum Hepatocyte Growth Factor (HGF) in Autistic Children with Severe Gastrointestinal Disease.

Russo A, Krigsman A, Jepson B, Wakefield A Biomark Insights. 2009; 4:181-90.

PMID: 20029653 PMC: 2796865. DOI: 10.4137/bmi.s3656.

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