Therapeutic Use of Human Renal Progenitor Cells for Kidney Regeneration

Overview

Journal Nat Rev Nephrol

Specialty Nephrology

Date 2015 Aug 5

PMID 26241019

Citations 39

Authors

Benedetta Bussolati

Giovanni Camussi

Affiliations

Soon will be listed here.

Abstract

The ability of the human kidney to repair itself is limited. Consequently, repeated injury can trigger a maladaptive response that is characterized by fibrosis and loss of renal function. The transcription patterns that characterize nephrogenesis in fetal renal progenitor cells (RPCs) are only partially activated during renal repair in adults. Nevertheless, evidence suggests that segment-restricted progenitor resident cells support renal healing in adults. In this Review, we discuss the evidence for the existence of functional human RPCs in adults and their role in renal repair, and consider the controversial issue of whether RPCs are a fixed population or arise through phenotypical plasticity of tubular cells that is mediated by the microenvironment. We also discuss the strategies for generating renal progenitor cells from pluripotent stem cells or differentiated cells and their use in therapy. Finally, we examine preclinical data on the therapeutic use of human fetal cells, adult progenitor cells and adult renal cells.

Citing Articles

How Stem and Progenitor Cells Can Affect Renal Diseases.

Montenegro F, Giannuzzi F, Picerno A, Cicirelli A, Stea E, Di Leo V Cells. 2024; 13(17.

PMID: 39273032 PMC: 11393889. DOI: 10.3390/cells13171460.

Sphingosine 1-phosphate protective effect on human proximal tubule cells submitted to an in vitro ischemia model: the role of JAK2/STAT3.

de Assis J, Grelle G, Fernandes A, da Silva Aniceto B, Pompeu P, de Mello F J Physiol Biochem. 2024; 80(4):831-843.

PMID: 39155330 DOI: 10.1007/s13105-024-01038-7.

Role of mitochondria in endogenous renal repair.

Kazeminia S, Eirin A Clin Sci (Lond). 2024; 138(15):963-973.

PMID: 39076039 PMC: 11410300. DOI: 10.1042/CS20231331.

Enriched human embryonic stem cells-derived CD133, CD24 renal progenitors engraft and restore function in a gentamicin-induced kidney injury in mice.

Bahrami M, Abbaszadeh H, Norouzian M, Abdollahifar M, Roozbahany N, Saber M Regen Ther. 2024; 27:506-518.

PMID: 38745839 PMC: 11091464. DOI: 10.1016/j.reth.2024.04.015.

Kidney tissue regeneration using bioactive scaffolds incorporated with differentiating extracellular vesicles and intermediate mesoderm cells.

Cha S, Rhim W, Kim J, Lee E, Lee S, Park J Biomater Res. 2023; 27(1):126.

PMID: 38049879 PMC: 10696796. DOI: 10.1186/s40824-023-00471-x.

References

Dekel B, Metsuyanim S, Schmidt-Ott K, Fridman E, Jacob-Hirsch J, Simon A . Multiple imprinted and stemness genes provide a link between normal and tumor progenitor cells of the developing human kidney. Cancer Res. 2006; 66(12):6040-9. DOI: 10.1158/0008-5472.CAN-05-4528. View

Bharadwaj S, Liu G, Shi Y, Wu R, Yang B, He T . Multipotential differentiation of human urine-derived stem cells: potential for therapeutic applications in urology. Stem Cells. 2013; 31(9):1840-56. DOI: 10.1002/stem.1424. View

Loverre A, Capobianco C, Ditonno P, Battaglia M, Grandaliano G, Schena F . Increase of proliferating renal progenitor cells in acute tubular necrosis underlying delayed graft function. Transplantation. 2008; 85(8):1112-9. DOI: 10.1097/TP.0b013e31816a8891. View

Oliver J, Maarouf O, Cheema F, Martens T, Al-Awqati Q . The renal papilla is a niche for adult kidney stem cells. J Clin Invest. 2004; 114(6):795-804. PMC: 516259. DOI: 10.1172/JCI20921. View

Carvalhosa R, Deambrosis I, Carrera P, Pasquino C, Rigo F, Ferrari M . Cystogenic potential of CD133+ progenitor cells of human polycystic kidneys. J Pathol. 2011; 225(1):129-41. DOI: 10.1002/path.2920. View

Li J, Ariunbold U, Suhaimi N, Sunn N, Guo J, McMahon J . Collecting duct-derived cells display mesenchymal stem cell properties and retain selective in vitro and in vivo epithelial capacity. J Am Soc Nephrol. 2014; 26(1):81-94. PMC: 4279727. DOI: 10.1681/ASN.2013050517. View

Smeets B, Angelotti M, Rizzo P, Dijkman H, Lazzeri E, Mooren F . Renal progenitor cells contribute to hyperplastic lesions of podocytopathies and crescentic glomerulonephritis. J Am Soc Nephrol. 2009; 20(12):2593-603. PMC: 2794226. DOI: 10.1681/ASN.2009020132. View

Hansson J, Hultenby K, Cramnert C, Ponten F, Jansson H, Lindgren D . Evidence for a morphologically distinct and functionally robust cell type in the proximal tubules of human kidney. Hum Pathol. 2014; 45(2):382-93. DOI: 10.1016/j.humpath.2013.10.003. View

Takasato M, Er P, Becroft M, Vanslambrouck J, Stanley E, Elefanty A . Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney. Nat Cell Biol. 2013; 16(1):118-26. DOI: 10.1038/ncb2894. View

10.

Kim K, Park B, Ihm H, Kim K, Jeong J, Chang J . Expression of stem cell marker CD133 in fetal and adult human kidneys and pauci-immune crescentic glomerulonephritis. Histol Histopathol. 2010; 26(2):223-32. DOI: 10.14670/HH-26.223. View

11.

Harari-Steinberg O, Metsuyanim S, Omer D, Gnatek Y, Gershon R, Pri-Chen S . Identification of human nephron progenitors capable of generation of kidney structures and functional repair of chronic renal disease. EMBO Mol Med. 2013; 5(10):1556-68. PMC: 3799579. DOI: 10.1002/emmm.201201584. View

12.

De Chiara L, Fagoonee S, Ranghino A, Bruno S, Camussi G, Tolosano E . Renal cells from spermatogonial germline stem cells protect against kidney injury. J Am Soc Nephrol. 2013; 25(2):316-28. PMC: 3904562. DOI: 10.1681/ASN.2013040367. View

13.

Araoka T, Mae S, Kurose Y, Uesugi M, Ohta A, Yamanaka S . Efficient and rapid induction of human iPSCs/ESCs into nephrogenic intermediate mesoderm using small molecule-based differentiation methods. PLoS One. 2014; 9(1):e84881. PMC: 3893162. DOI: 10.1371/journal.pone.0084881. View

14.

Barker N, Rookmaaker M, Kujala P, Ng A, Leushacke M, Snippert H . Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development. Cell Rep. 2012; 2(3):540-52. DOI: 10.1016/j.celrep.2012.08.018. View

15.

Buzhor E, Omer D, Harari-Steinberg O, Dotan Z, Vax E, Pri-Chen S . Reactivation of NCAM1 defines a subpopulation of human adult kidney epithelial cells with clonogenic and stem/progenitor properties. Am J Pathol. 2013; 183(5):1621-1633. DOI: 10.1016/j.ajpath.2013.07.034. View

16.

Kusaba T, Humphreys B . Controversies on the origin of proliferating epithelial cells after kidney injury. Pediatr Nephrol. 2013; 29(4):673-9. PMC: 3944107. DOI: 10.1007/s00467-013-2669-3. View

17.

Boyle S, Misfeldt A, Chandler K, Deal K, Southard-Smith E, Mortlock D . Fate mapping using Cited1-CreERT2 mice demonstrates that the cap mesenchyme contains self-renewing progenitor cells and gives rise exclusively to nephronic epithelia. Dev Biol. 2007; 313(1):234-45. PMC: 2699557. DOI: 10.1016/j.ydbio.2007.10.014. View

18.

Crisan M, Yap S, Casteilla L, Chen C, Corselli M, Park T . A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell. 2008; 3(3):301-13. DOI: 10.1016/j.stem.2008.07.003. View

19.

Kreidberg J, Sariola H, LORING J, Maeda M, Pelletier J, Housman D . WT-1 is required for early kidney development. Cell. 1993; 74(4):679-91. DOI: 10.1016/0092-8674(93)90515-r. View

20.

Lazzeri E, Crescioli C, Ronconi E, Mazzinghi B, Sagrinati C, Netti G . Regenerative potential of embryonic renal multipotent progenitors in acute renal failure. J Am Soc Nephrol. 2007; 18(12):3128-38. DOI: 10.1681/ASN.2007020210. View