Wobble↔Watson-Crick Tautomeric Transitions in the Homo-purine DNA Mismatches: a Key to the Intimate Mechanisms of the Spontaneous Transversions

Overview

Journal J Biomol Struct Dyn

Specialties Biochemistry
Molecular Biology

Date 2015 Aug 4

PMID 26237090

Citations 11

Authors

Olha O Brovarets

Dmytro M Hovorun

Affiliations

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Abstract

The intrinsic capability of the homo-purine DNA base mispairs to perform wobble↔Watson-Crick/Topal-Fresco tautomeric transitions via the sequential intrapair double proton transfer was discovered for the first time using QM (MP2/DFT) and QTAIM methodologies that are crucial for understanding the microstructural mechanisms of the spontaneous transversions.

Citing Articles

The A·T(rWC)/A·T(H)/A·T(rH) ↔ A·T*(rw)/A·T*(w)/A·T*(rw) mutagenic tautomerization sequential proton transfer: a QM/QTAIM study.

Brovarets O, Tsiupa K, Hovorun D RSC Adv. 2022; 8(24):13433-13445.

PMID: 35542561 PMC: 9079753. DOI: 10.1039/c8ra01446a.

Novel mechanisms of the conformational transformations of the biologically important G·C nucleobase pairs in Watson-Crick, Hoogsteen and wobble configurations the mutual rotations of the bases around the intermolecular H-bonds: a QM/QTAIM study.

Brovarets O, Muradova A, Hovorun D RSC Adv. 2022; 11(41):25700-25730.

PMID: 35478902 PMC: 9036977. DOI: 10.1039/d0ra08702e.

A Quantum-Mechanical Looking Behind the Scene of the Classic G·C Nucleobase Pairs Tautomerization.

Brovarets O, Muradova A, Hovorun D Front Chem. 2020; 8:574454.

PMID: 33330362 PMC: 7732530. DOI: 10.3389/fchem.2020.574454.

Novel Tautomerisation Mechanisms of the Biologically Important Conformers of the Reverse Löwdin, Hoogsteen, and Reverse Hoogsteen G·C DNA Base Pairs Proton Transfer: A Quantum-Mechanical Survey.

Brovarets O, Oliynyk T, Hovorun D Front Chem. 2019; 7:597.

PMID: 31620420 PMC: 6759773. DOI: 10.3389/fchem.2019.00597.

The Role of Proton Transfer on Mutations.

Srivastava R Front Chem. 2019; 7:536.

PMID: 31497591 PMC: 6712085. DOI: 10.3389/fchem.2019.00536.