Predicted Impact of Nicotine Reduction on Smokers with Affective Disorders

Overview

Journal Tob Regul Sci

Date 2015 Aug 4

PMID 26236765

Citations 10

Authors

Diann E Gaalema

Mollie E Miller

Jennifer W Tidey

Affiliations

Soon will be listed here.

Abstract

Objectives: In 2009 the FDA acquired the authority to reduce the nicotine content in cigarettes if appropriate for public health, prompting research to evaluate the implications of this policy scientifically. Studies in non-psychiatric populations show that reducing the nicotine content of cigarettes to non-addictive levels reduces smoking rates and nicotine dependence. However, few studies have examined this hypothesis in vulnerable populations.

Methods: In this narrative review we examined the extant literature on the effects of nicotine reduction or cessation on symptoms of withdrawal, as well as psychiatric symptoms, among those with affective disorders.

Results: Following initial withdrawal from nicotine, smokers with affective disorders experience more severe mood disruption than smokers without these disorders. Use of very low nicotine content (VLNC) cigarettes during abstinence may help mitigate the mood-disrupting effects of initial abstinence. Once the initial effects of nicotine withdrawal on mood have passed, longer-term abstinence is associated with psychiatric improvement rather than worsening.

Conclusions: These findings suggest that if a national nicotine reduction policy were to be implemented, smokers with affective disorders would need additional support to overcome initial withdrawal but that long-term outcomes would likely be positive.

Citing Articles

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Nicotine Reduction in Cigarettes: Literature Review and Gap Analysis.

Berman M, Glasser A Nicotine Tob Res. 2019; 21(Suppl 1):S133-S144.

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Potential Moderating Effects of Psychiatric Diagnosis and Symptom Severity on Subjective and Behavioral Responses to Reduced Nicotine Content Cigarettes.

Gaalema D, Tidey J, Davis D, Sigmon S, Heil S, Stitzer M Nicotine Tob Res. 2019; 21(Suppl 1):S29-S37.

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Very Low Nicotine Content Cigarettes Disrupt the Feedback Loop of Affective States and Smoking Behavior.

Robinson J, Kypriotakis G, alAbsi M, Denlinger-Apte R, Drobes D, Leischow S Nicotine Tob Res. 2019; 22(8):1294-1300.

PMID: 31701153 PMC: 7364840. DOI: 10.1093/ntr/ntz209.

Modeling nicotine regulation: A review of studies in smokers with mental health conditions.

Tidey J, Davis D, Miller M, Pericot-Valverde I, Denlinger-Apte R, Gaalema D Prev Med. 2018; 117:30-37.

PMID: 30343684 PMC: 7467778. DOI: 10.1016/j.ypmed.2018.07.003.

References

Kahler C, Brown R, Ramsey S, Niaura R, Abrams D, Goldstein M . Negative mood, depressive symptoms, and major depression after smoking cessation treatment in smokers with a history of major depressive disorder. J Abnorm Psychol. 2002; 111(4):670-5. DOI: 10.1037//0021-843x.111.4.670. View

Benowitz N, Henningfield J . Reducing the nicotine content to make cigarettes less addictive. Tob Control. 2013; 22 Suppl 1:i14-7. PMC: 3632983. DOI: 10.1136/tobaccocontrol-2012-050860. View

Dierker L, Donny E . The role of psychiatric disorders in the relationship between cigarette smoking and DSM-IV nicotine dependence among young adults. Nicotine Tob Res. 2008; 10(3):439-46. PMC: 2679531. DOI: 10.1080/14622200801901898. View

Breslau N, Kilbey M, Andreski P . Nicotine withdrawal symptoms and psychiatric disorders: findings from an epidemiologic study of young adults. Am J Psychiatry. 1992; 149(4):464-9. DOI: 10.1176/ajp.149.4.464. View

Anthenelli R, Morris C, Ramey T, DuBrava S, Tsilkos K, Russ C . Effects of varenicline on smoking cessation in adults with stably treated current or past major depression: a randomized trial. Ann Intern Med. 2013; 159(6):390-400. DOI: 10.7326/0003-4819-159-6-201309170-00005. View

Tidey J, Colby S, Xavier E . Effects of smoking abstinence on cigarette craving, nicotine withdrawal, and nicotine reinforcement in smokers with and without schizophrenia. Nicotine Tob Res. 2013; 16(3):326-34. PMC: 3920337. DOI: 10.1093/ntr/ntt152. View

Prochaska J, Hall S, Tsoh J, Eisendrath S, Rossi J, Redding C . Treating tobacco dependence in clinically depressed smokers: effect of smoking cessation on mental health functioning. Am J Public Health. 2007; 98(3):446-8. PMC: 2253568. DOI: 10.2105/AJPH.2006.101147. View

Burgess E, Brown R, Kahler C, Niaura R, Abrams D, Goldstein M . Patterns of change in depressive symptoms during smoking cessation: who's at risk for relapse?. J Consult Clin Psychol. 2002; 70(2):356-61. PMC: 1808225. DOI: 10.1037//0022-006x.70.2.356. View

. Practice guideline for the treatment of patients with nicotine dependence. American Psychiatric Association. Am J Psychiatry. 1996; 153(10 Suppl):1-31. DOI: 10.1176/ajp.153.10.1. View

10.

MacPherson L, Tull M, Matusiewicz A, Rodman S, Strong D, Kahler C . Randomized controlled trial of behavioral activation smoking cessation treatment for smokers with elevated depressive symptoms. J Consult Clin Psychol. 2010; 78(1):55-61. PMC: 3108050. DOI: 10.1037/a0017939. View

11.

Benowitz N, Henningfield J . Establishing a nicotine threshold for addiction. The implications for tobacco regulation. N Engl J Med. 1994; 331(2):123-5. DOI: 10.1056/NEJM199407143310212. View

12.

McFall M, Saxon A, Malte C, Chow B, Bailey S, Baker D . Integrating tobacco cessation into mental health care for posttraumatic stress disorder: a randomized controlled trial. JAMA. 2010; 304(22):2485-93. PMC: 4218733. DOI: 10.1001/jama.2010.1769. View

13.

Mannucci C, Pieratti A, Firenzuoli F, Caputi A, Calapai G . Serotonin mediates beneficial effects of Hypericum perforatum on nicotine withdrawal signs. Phytomedicine. 2007; 14(10):645-51. DOI: 10.1016/j.phymed.2007.06.005. View

14.

Marshall E, Johnson K, Bergman J, Gibson L, Zvolensky M . Anxiety sensitivity and panic reactivity to bodily sensations: relation to quit-day (acute) nicotine withdrawal symptom severity among daily smokers making a self-guided quit attempt. Exp Clin Psychopharmacol. 2009; 17(5):356-364. PMC: 2913276. DOI: 10.1037/a0016883. View

15.

Dedert E, Calhoun P, Harper L, Dutton C, McClernon F, Beckham J . Smoking withdrawal in smokers with and without posttraumatic stress disorder. Nicotine Tob Res. 2011; 14(3):372-6. PMC: 3281234. DOI: 10.1093/ntr/ntr142. View

16.

Kawachi I, Colditz G, Ascherio A, Rimm E, Giovannucci E, Stampfer M . Prospective study of phobic anxiety and risk of coronary heart disease in men. Circulation. 1994; 89(5):1992-7. DOI: 10.1161/01.cir.89.5.1992. View

17.

Kleber H, Weiss R, Anton Jr R, George T, Greenfield S, Kosten T . Treatment of patients with substance use disorders, second edition. American Psychiatric Association. Am J Psychiatry. 2007; 164(4 Suppl):5-123. View

18.

Gross J, Lee J, Stitzer M . Nicotine-containing versus de-nicotinized cigarettes: effects on craving and withdrawal. Pharmacol Biochem Behav. 1997; 57(1-2):159-65. DOI: 10.1016/s0091-3057(96)00309-7. View

19.

West R, Baker C, Cappelleri J, Bushmakin A . Effect of varenicline and bupropion SR on craving, nicotine withdrawal symptoms, and rewarding effects of smoking during a quit attempt. Psychopharmacology (Berl). 2007; 197(3):371-7. DOI: 10.1007/s00213-007-1041-3. View

20.

Callaghan R, Veldhuizen S, Jeysingh T, Orlan C, Graham C, Kakouris G . Patterns of tobacco-related mortality among individuals diagnosed with schizophrenia, bipolar disorder, or depression. J Psychiatr Res. 2013; 48(1):102-10. DOI: 10.1016/j.jpsychires.2013.09.014. View