Treatment Modalities of Necrobiosis Lipoidica: A Concise Systematic Review

Overview

Journal Dermatol Reports

Publisher PagePress

Specialty Dermatology

Date 2015 Aug 4

PMID 26236446

Citations 3

Authors

Amir Feily

Shadi Mehraban

Affiliations

Soon will be listed here.

Abstract

Necrobiosis lipoidica (NL) is a rare inflammatory granulomatous skin disorder closely associated with diabetes mellitus. The aim of this paper is to review and discuss all the treatment modalities proposed and tested for this disease. A systematic review of the existing literature was conducted to investigate all the available data and summarize all the clinical trials, case reports and original articles on NL. Two major databases (PubMed and Google Scholar) were used. We have examined about 70 articles. Numerous treatment modalities have been currently investigated to compare recalcitrant NL. Being rare, most of the studies regarding this disease are case reports or small-scale clinical trials. We have found that, in spite of plentiful investigations carried out during the years, there is no treatment modality that has proved to be utterly satisfactory in treating NL.

Citing Articles

The Role of Lasers in Connective Tissue and Inflammatory Dermatoses: A 10-Year Retrospective Review of 60 Patients in a UK Tertiary Laser Clinic.

Asfour L, Ismail D, Madan V Indian Dermatol Online J. 2023; 14(5):616-623.

PMID: 37727556 PMC: 10506828. DOI: 10.4103/idoj.idoj_439_22.

Necrobiosis Lipoidica Affecting the Leg: What Is the Best Treatment in a Patient with Very High Aesthetic Demand?.

Baccarani A, De Maria F, Pappalardo M, Pedone A, De Santis G Plast Reconstr Surg Glob Open. 2020; 8(7):e3000.

PMID: 32802684 PMC: 7413758. DOI: 10.1097/GOX.0000000000003000.

Concomitant necrobiosis lipoidica and splenic abscess.

Fekaj E J Surg Case Rep. 2019; 2019(3):rjz088.

PMID: 30949338 PMC: 6439504. DOI: 10.1093/jscr/rjz088.

References

Taniguchi Y, Sakamoto T, Shimizu M . A case of necrobiosis lipoidica treated with systemic corticosteroid. J Dermatol. 1993; 20(5):304-7. DOI: 10.1111/j.1346-8138.1993.tb01396.x. View

OReilly K, Chu J, Meehan S, Heller P, Ashinoff R, Gruson L . Necrobiosis lipoidica. Dermatol Online J. 2011; 17(10):18. View

Noz K, Korstanje M, Vermeer B . Ulcerating necrobiosis lipoidica effectively treated with pentoxifylline. Clin Exp Dermatol. 1993; 18(1):78-9. DOI: 10.1111/j.1365-2230.1993.tb00977.x. View

Kreuter A, Knierim C, Stucker M, Pawlak F, Rotterdam S, Altmeyer P . Fumaric acid esters in necrobiosis lipoidica: results of a prospective noncontrolled study. Br J Dermatol. 2005; 153(4):802-7. DOI: 10.1111/j.1365-2133.2005.06762.x. View

Sparrow G, Abell E . Granuloma annulare and necrobiosis lipoidica treated by jet injector. Br J Dermatol. 1975; 93(1):85-9. DOI: 10.1111/j.1365-2133.1975.tb06481.x. View

Radakovic S, Weber M, Tanew A . Dramatic response of chronic ulcerating necrobiosis lipoidica to ultraviolet A1 phototherapy. Photodermatol Photoimmunol Photomed. 2010; 26(6):327-9. DOI: 10.1111/j.1600-0781.2010.00543.x. View

Heng M, Song M, Heng M . Healing of necrobiotic ulcers with antiplatelet therapy. Correlation with plasma thromboxane levels. Int J Dermatol. 1989; 28(3):195-7. DOI: 10.1111/j.1365-4362.1989.tb02465.x. View

Berking C, Hegyi J, Arenberger P, Ruzicka T, Jemec G . Photodynamic therapy of necrobiosis lipoidica--a multicenter study of 18 patients. Dermatology. 2008; 218(2):136-9. DOI: 10.1159/000182259. View

Gambichler T, Kreuter A, Freitag M, Pawlak F, Brockmeyer N, Altmeyer P . Clearance of necrobiosis lipoidica with fumaric acid esters. Dermatology. 2003; 207(4):422-4. DOI: 10.1159/000074133. View

10.

Petrova G, Levin G . [The blood rheological indices of patients with necrobiosis lipoidica]. Vestn Dermatol Venerol. 1989; (12):45-8. View

11.

Cohen O, Yaniv R, Karasik A, Trau H . Necrobiosis lipoidica and diabetic control revisited. Med Hypotheses. 1996; 46(4):348-50. DOI: 10.1016/s0306-9877(96)90184-x. View

12.

Beattie P, Dawe R, Ibbotson S, Ferguson J . UVA1 phototherapy for treatment of necrobiosis lipoidica. Clin Exp Dermatol. 2006; 31(2):235-8. DOI: 10.1111/j.1365-2230.2005.02059.x. View

13.

Narbutt J, Torzecka J, Sysa-Jedrzejowska A, Zalewska A . Long-term results of topical PUVA in necrobiosis lipoidica. Clin Exp Dermatol. 2005; 31(1):65-7. DOI: 10.1111/j.1365-2230.2005.01962.x. View

14.

Mendoza V, Vahid B, Kozic H, Weibel S . Clinical and pathologic manifestations of necrobiosis lipoidica-like skin involvement in sarcoidosis. Joint Bone Spine. 2007; 74(6):647-9. DOI: 10.1016/j.jbspin.2006.12.007. View

15.

de Rie M, Sommer A, Hoekzema R, Neumann H . Treatment of necrobiosis lipoidica with topical psoralen plus ultraviolet A. Br J Dermatol. 2002; 147(4):743-7. DOI: 10.1046/j.1365-2133.2002.04856.x. View

16.

Dwyer C, Dick D . Ulceration in necrobiosis lipoidica--a case report and study. Clin Exp Dermatol. 1993; 18(4):366-9. DOI: 10.1111/j.1365-2230.1993.tb02220.x. View

17.

Patsatsi A, Kyriakou A, Sotiriadis D . Necrobiosis lipoidica: early diagnosis and treatment with tacrolimus. Case Rep Dermatol. 2011; 3(1):89-93. PMC: 3094681. DOI: 10.1159/000327936. View

18.

Aslan E, Korber A, Grabbe S, Dissemond J . [Successful therapy of ulcerated necrobiosis lipoidica non diabeticorum with cyclosporine A]. Hautarzt. 2007; 58(8):684-8. DOI: 10.1007/s00105-006-1282-9. View

19.

Kostler E, Wollina U . Ulcerated necrobiosis lipoidica: a combined treatment approach with dermatosurgery and PUVA. Int J Low Extrem Wounds. 2005; 2(4):243-5. DOI: 10.1177/1534734603260680. View

20.

Weisz G, Ramon Y, Waisman D, Melamed Y . Treatment of necrobiosis lipoidica diabeticorum by hyperbaric oxygen. Acta Derm Venereol. 1993; 73(6):447-8. DOI: 10.2340/0001555573447448. View