» Articles » PMID: 26234180

Nonenzymatic Glycation and Degree of Mineralization Are Higher in Bone From Fractured Patients With Type 1 Diabetes Mellitus

Overview
Date 2015 Aug 4
PMID 26234180
Citations 53
Authors
Affiliations
Soon will be listed here.
Abstract

Low-energy fractures are frequent complications in type 1 diabetes mellitus patients (T1DM). Modifications of bone intrinsic composition might be a potential cause of fragility observed in diabetic subjects. Advanced glycation end products (AGEs) were found in numerous connective tissues from T1DM patients. However, whether AGEs are present at high levels in bone matrix from diabetic subjects is unknown. Moreover, whether elevated AGEs in the bone matrix impair mineralization has not been addressed in humans. The purposes of this study were 1) to determine whether bone matrix from fracturing and nonfracturing T1DM contained more AGEs than bone from healthy patients (CTL), and 2) to compare the degree of mineralization of bone and hardness between fracturing and nonfracturing T1DM versus CTL. We analyzed iliac crest bone biopsies from 5 fracturing T1DM patients, 5 nonfracturing T1DM patients, and 5 healthy subjects, all age- and sex-matched. AGEs (pentosidine) in bone matrix was measured by high-performance liquid chromatography separately in trabecular and cortical bone. The degree of mineralization of bone (DMB) was assessed by digitized microradiography, and mechanical properties by micro- and nanohardness tests. Trabecular bone from fracturing T1DM exhibited significantly higher levels of pentosidine than CTL (p = 0.04) and was more mineralized than nonfracturing T1DM (p = 0.04) and CTL (p = 0.04). Trabecular bone was not significantly different in pentosidine between nonfracturing T1DM and CTL. Cortical bone from nonfracturing T1DM was not significantly different from CTL. Positive correlations were found between HbA1c and pentosidine (r' = 0.79, p < 0.003) and between HbA1c and DMB (r' = 0.64, p < 0.02). Both modifications could lead to less flexible bone (reduced modulus of elasticity) and a tendency toward low-energy fractures in T1DM patients.

Citing Articles

Long-duration type 1 diabetes is associated with deficient cortical bone mechanical behavior and altered matrix composition in human femoral bone.

Emerzian S, Chow J, Behzad R, Unal M, Brooks D, Wu I J Bone Miner Res. 2024; 40(1):87-99.

PMID: 39561104 PMC: 11700620. DOI: 10.1093/jbmr/zjae184.


Enzymatic and Non-enzymatic Collagen Cross-Links and Fracture Occurrence in Type 1 Diabetes Patients.

Paschalis E, Gamsjaeger S, Graeff-Armas L, Bare S, Recker R, Akhter M Calcif Tissue Int. 2024; 115(3):328-333.

PMID: 38871838 DOI: 10.1007/s00223-024-01243-y.


Advanced glycation end products are not associated with bone mineral density, trabecular bone score, and bone turnover markers in adults with and without type 1 diabetes: a cross-sectional study.

Coll J, Turcotte A, Leslie W, Michou L, Weisnagel S, Mac-Way F JBMR Plus. 2024; 8(3):ziad018.

PMID: 38505219 PMC: 10945729. DOI: 10.1093/jbmrpl/ziad018.


Diabetes and Osteoporosis.

Prasad T, Arjunan D, Pal R, Bhadada S Indian J Orthop. 2023; 57(Suppl 1):209-217.

PMID: 38107797 PMC: 10721588. DOI: 10.1007/s43465-023-01049-4.


Bone Structure and Turnover in Postmenopausal Women With Long-Standing Type 1 Diabetes.

Shah V, Qui S, Stoneback J, Qamar L, Ferguson V, Kohrt W JBMR Plus. 2023; 7(11):e10831.

PMID: 38025041 PMC: 10652172. DOI: 10.1002/jbm4.10831.


References
1.
Farr J, Drake M, Amin S, Melton 3rd L, McCready L, Khosla S . In vivo assessment of bone quality in postmenopausal women with type 2 diabetes. J Bone Miner Res. 2013; 29(4):787-95. PMC: 3961509. DOI: 10.1002/jbmr.2106. View

2.
Polly B, Yuya P, Akhter M, Recker R, Turner J . Intrinsic material properties of trabecular bone by nanoindentation testing of biopsies taken from healthy women before and after menopause. Calcif Tissue Int. 2012; 90(4):286-93. DOI: 10.1007/s00223-012-9575-8. View

3.
Nicodemus K, Folsom A . Type 1 and type 2 diabetes and incident hip fractures in postmenopausal women. Diabetes Care. 2001; 24(7):1192-7. DOI: 10.2337/diacare.24.7.1192. View

4.
Vashishth D . The role of the collagen matrix in skeletal fragility. Curr Osteoporos Rep. 2007; 5(2):62-6. DOI: 10.1007/s11914-007-0004-2. View

5.
Neumann T, Lodes S, Kastner B, Franke S, Kiehntopf M, Lehmann T . High serum pentosidine but not esRAGE is associated with prevalent fractures in type 1 diabetes independent of bone mineral density and glycaemic control. Osteoporos Int. 2014; 25(5):1527-33. DOI: 10.1007/s00198-014-2631-7. View