Determined to Fail--the Role of Genetic Mechanisms in Heart Failure

Overview

Journal Curr Heart Fail Rep

Publisher Current Science

Date 2015 Aug 3

PMID 26233853

Citations 7

Authors

Elham Kayvanpour

Hugo A Katus

Benjamin Meder

Affiliations

Soon will be listed here.

Abstract

Genetic variants contribute to several steps during heart failure pathophysiology. The mechanisms include frequent polymorphisms that increase the susceptibility to heart failure in the general population and rare variants as causes of an underlying cardiomyopathy. In this review, we highlight recent discoveries made by genetic approaches and provide an outlook onto the role of epigenetic modifiers of heart failure.

Citing Articles

[Precision medicine in the diagnostics and treatment of cardiomyopathies : State of the art].

Vetter N, Meder B Herz. 2025; .

PMID: 40080176 DOI: 10.1007/s00059-025-05296-z.

Identification of p.C335R Variant in a Large Family with Dilated Cardiomyopathy and Conduction Disease.

Sedaghat-Hamedani F, Rebs S, El-Battrawy I, Chasan S, Krause T, Haas J Int J Mol Sci. 2021; 22(23).

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-Associated Ventricular Arrhythmias in a Patient with Structurally Normal Heart.

Vakhrushev Y, Kozyreva A, Semenov A, Sokolnikova P, Lubimtseva T, Lebedev D Genes (Basel). 2021; 12(1).

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Clinical and genetic insights into non-compaction: a meta-analysis and systematic review on 7598 individuals.

Kayvanpour E, Sedaghat-Hamedani F, Gi W, Tugrul O, Amr A, Haas J Clin Res Cardiol. 2019; 108(11):1297-1308.

PMID: 30980206 DOI: 10.1007/s00392-019-01465-3.

Precision medicine for cardiovascular disease : Learning lessons from cardiomyopathies.

Sedaghat-Hamedani F, Katus H, Meder B Herz. 2017; 43(2):123-130.

PMID: 29260236 DOI: 10.1007/s00059-017-4667-x.

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