Human Infections with Staphylococcus Aureus CC398

Overview

Journal Curr Environ Health Rep

Specialty Environmental Health

Date 2015 Aug 2

PMID 26231241

Citations 34

Authors

Tara C Smith

Shylo E Wardyn

Affiliations

Soon will be listed here.

Abstract

Staphylococcus aureus isolates belonging to clonal cluster 398 (CC398) have emerged over the previous decade as a risk to livestock workers. Though most of the research to date has focused on colonization with these strains, a number of infections have also been documented, ranging from mild skin infections to more serious invasive infections and even death. Here, we review existing reports of human infections with CC398 and discuss their geographic distribution, general characteristics, and implications for future research. We identified 74 publications describing CC398 infections in humans in 19 different countries, suggesting this is an emerging worldwide issue.

Citing Articles

Time-calibrated phylogenetic and chromosomal mobilome analyses of Staphylococcus aureus CC398 reveal geographical and host-related evolution.

Fernandez J, Egli A, Overesch G, Perreten V Nat Commun. 2024; 15(1):5526.

PMID: 38951499 PMC: 11217367. DOI: 10.1038/s41467-024-49644-9.

Bleeding skin lesions in gestating sows of a piglet producing farm in Austria.

Schwarz L, Hamar F, Bernreiter-Hofer T, Loncaric I, Arnold M, Voglmayr T Porcine Health Manag. 2023; 9(1):52.

PMID: 37964382 PMC: 10647148. DOI: 10.1186/s40813-023-00348-4.

Methicillin-resistant and methicillin-sensitive in pork industry workers, Catalonia, Spain.

Quero S, Serras-Pujol M, Parraga-Nino N, Torres C, Navarro M, Vilamala A One Health. 2023; 16:100538.

PMID: 37363245 PMC: 10288084. DOI: 10.1016/j.onehlt.2023.100538.

Molecular Characterization of Methicillin-Resistant Staphylococci from the Dairy Value Chain in Two Indian States.

Dey T, Shome B, Bandyopadhyay S, Goyal N, Lundkvist A, Deka R Pathogens. 2023; 12(2).

PMID: 36839616 PMC: 9965176. DOI: 10.3390/pathogens12020344.

High-Throughput Mutagenesis Reveals a Role for Antimicrobial Resistance- and Virulence-Associated Mobile Genetic Elements in Staphylococcus aureus Host Adaptation.

Ba X, Matuszewska M, Kalmar L, Fan J, Zou G, Corander D Microbiol Spectr. 2023; :e0421322.

PMID: 36815781 PMC: 10101091. DOI: 10.1128/spectrum.04213-22.

References

Vindel A, Cuevas O, Cercenado E, Marcos C, Bautista V, Castellares C . Methicillin-resistant Staphylococcus aureus in Spain: molecular epidemiology and utility of different typing methods. J Clin Microbiol. 2009; 47(6):1620-7. PMC: 2691083. DOI: 10.1128/JCM.01579-08. View

Uhlemann A, Porcella S, Trivedi S, Sullivan S, Hafer C, Kennedy A . Identification of a highly transmissible animal-independent Staphylococcus aureus ST398 clone with distinct genomic and cell adhesion properties. mBio. 2012; 3(2). PMC: 3302565. DOI: 10.1128/mBio.00027-12. View

Huijsdens X, van Dijke B, Spalburg E, van Santen-Verheuvel M, Heck M, Pluister G . Community-acquired MRSA and pig-farming. Ann Clin Microbiol Antimicrob. 2006; 5:26. PMC: 1654169. DOI: 10.1186/1476-0711-5-26. View

Yao D, Yu F, Qin Z, Chen C, He S, Chen Z . Molecular characterization of Staphylococcus aureus isolates causing skin and soft tissue infections (SSTIs). BMC Infect Dis. 2010; 10:133. PMC: 2889999. DOI: 10.1186/1471-2334-10-133. View

Wu D, Li X, Yang Y, Zheng Y, Wang C, Deng L . Superantigen gene profiles and presence of exfoliative toxin genes in community-acquired meticillin-resistant Staphylococcus aureus isolated from Chinese children. J Med Microbiol. 2010; 60(Pt 1):35-45. DOI: 10.1099/jmm.0.023465-0. View

Monecke S, Kuhnert P, Hotzel H, Slickers P, Ehricht R . Microarray based study on virulence-associated genes and resistance determinants of Staphylococcus aureus isolates from cattle. Vet Microbiol. 2007; 125(1-2):128-40. DOI: 10.1016/j.vetmic.2007.05.016. View

Potel C, Alvarez-Fernandez M, Constenla L, Alvarez P, Perez S . First human isolates of methicillin-resistant Staphylococcus aureus sequence type 398 in Spain. Eur J Clin Microbiol Infect Dis. 2010; 29(3):351-2. DOI: 10.1007/s10096-009-0860-z. View

Rijnders M, Deurenberg R, Boumans M, Hoogkamp-Korstanje J, Beisser P, Stobberingh E . Population structure of Staphylococcus aureus strains isolated from intensive care unit patients in the netherlands over an 11-year period (1996 to 2006). J Clin Microbiol. 2009; 47(12):4090-5. PMC: 2786662. DOI: 10.1128/JCM.00820-09. View

Aarestrup F, Cavaco L, Hasman H . Decreased susceptibility to zinc chloride is associated with methicillin resistant Staphylococcus aureus CC398 in Danish swine. Vet Microbiol. 2009; 142(3-4):455-7. DOI: 10.1016/j.vetmic.2009.10.021. View

10.

Bhat M, Dumortier C, Taylor B, Miller M, Vasquez G, Yunen J . Staphylococcus aureus ST398, New York City and Dominican Republic. Emerg Infect Dis. 2009; 15(2):285-7. PMC: 2657615. DOI: 10.3201/eid1502.080609. View

11.

Larson K, Smith T, Donham K . Self-reported methicillin-resistant Staphylococcus aureus infection in USA pork producers. Ann Agric Environ Med. 2010; 17(2):331-4. View

12.

Mammina C, Cala C, Bonura C, Di Carlo P, Aleo A, Fasciana T . Polyclonal non multiresistant methicillin resistant Staphylococcus aureus isolates from clinical cases of infection occurring in Palermo, Italy, during a one-year surveillance period. Ann Clin Microbiol Antimicrob. 2012; 11:17. PMC: 3473248. DOI: 10.1186/1476-0711-11-17. View

13.

Welinder-Olsson C, Floren-Johansson K, Larsson L, Oberg S, Karlsson L, Ahren C . Infection with Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus t034. Emerg Infect Dis. 2008; 14(8):1271-2. PMC: 2600383. DOI: 10.3201/eid1408.071427. View

14.

Zhao C, Liu Y, Zhao M, Liu Y, Yu Y, Chen H . Characterization of community acquired Staphylococcus aureus associated with skin and soft tissue infection in Beijing: high prevalence of PVL+ ST398. PLoS One. 2012; 7(6):e38577. PMC: 3368899. DOI: 10.1371/journal.pone.0038577. View

15.

Lina G, Piemont Y, Bes M, Peter M, Gauduchon V, Vandenesch F . Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia. Clin Infect Dis. 1999; 29(5):1128-32. DOI: 10.1086/313461. View

16.

Kock R, Brakensiek L, Mellmann A, Kipp F, Henderikx M, Harmsen D . Cross-border comparison of the admission prevalence and clonal structure of meticillin-resistant Staphylococcus aureus. J Hosp Infect. 2009; 71(4):320-6. DOI: 10.1016/j.jhin.2008.12.001. View

17.

Cui S, Li J, Hu C, Jin S, Li F, Guo Y . Isolation and characterization of methicillin-resistant Staphylococcus aureus from swine and workers in China. J Antimicrob Chemother. 2009; 64(4):680-3. DOI: 10.1093/jac/dkp275. View

18.

Uhlemann A, Hafer C, Miko B, Sowash M, Sullivan S, Shu Q . Emergence of sequence type 398 as a community- and healthcare-associated methicillin-susceptible staphylococcus aureus in northern Manhattan. Clin Infect Dis. 2013; 57(5):700-3. PMC: 3739468. DOI: 10.1093/cid/cit375. View

19.

Jimenez J, Velez L, Mediavilla J, Ocampo A, Vanegas J, Rodriguez E . Livestock-associated methicillin-susceptible Staphylococcus aureus ST398 infection in woman, Colombia. Emerg Infect Dis. 2011; 17(10):1970-1. PMC: 3310681. DOI: 10.3201/eid1710.110638. View

20.

van Loo I, Huijsdens X, Tiemersma E, de Neeling A, van de Sande-Bruinsma N, Beaujean D . Emergence of methicillin-resistant Staphylococcus aureus of animal origin in humans. Emerg Infect Dis. 2008; 13(12):1834-9. PMC: 2876750. DOI: 10.3201/eid1312.070384. View