Long Non-Coding RNAs: The Key Players in Glioma Pathogenesis

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2015 Aug 1

PMID 26230711

Citations 53

Authors

Karrie Mei-Yee Kiang

Xiao-Qin Zhang

Gilberto Ka-Kit Leung

Affiliations

Soon will be listed here.

Abstract

Long non-coding RNAs (LncRNAs) represent a novel class of RNAs with no functional protein-coding ability, yet it has become increasingly clear that interactions between lncRNAs with other molecules are responsible for important gene regulatory functions in various contexts. Given their relatively high expressions in the brain, lncRNAs are now thought to play important roles in normal brain development as well as diverse disease processes including gliomagenesis. Intriguingly, certain lncRNAs are closely associated with the initiation, differentiation, progression, recurrence and stem-like characteristics in glioma, and may therefore be exploited for the purposes of sub-classification, diagnosis and prognosis. LncRNAs may also serve as potential therapeutic targets as well as a novel biomarkers in the treatment of glioma. In this article, the functional aspects of lncRNAs, particularly within the central nervous system (CNS), will be briefly discussed, followed by highlights of the important roles of lncRNAs in mediating critical steps during glioma development. In addition, the key lncRNA players and their possible mechanistic pathways associated with gliomagenesis will be addressed.

Citing Articles

Hidden regulators: the emerging roles of lncRNAs in brain development and disease.

Alammari F, Al-Hujaily E, Alshareeda A, Albarakati N, Al-Sowayan B Front Neurosci. 2024; 18:1392688.

PMID: 38841098 PMC: 11150811. DOI: 10.3389/fnins.2024.1392688.

LncRNA NDUFA6-DT: A Comprehensive Analysis of a Potential LncRNA Biomarker and Its Regulatory Mechanisms in Gliomas.

Huang R, Kong Y, Luo Z, Li Q Genes (Basel). 2024; 15(4).

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Expression of lncRNAs in glioma: A lighthouse for patients with glioma.

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Zhang Z, Ren P, Cao Y, Wang T, Huang G, Li Y CNS Neurosci Ther. 2023; 29(11):3430-3445.

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An Integrated Immune-Related Bioinformatics Analysis in Glioma: Prognostic Signature's Identification and Multi-Omics Mechanisms' Exploration.

Fan X, Zhang L, Huang J, Zhong Y, Fan Y, Zhou T Front Genet. 2022; 13:889629.

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