Profile of Collagen Gene Expression in the Glenohumeral Capsule of Patients with Traumatic Anterior Instability of the Shoulder

Overview

Journal Rev Bras Ortop

Specialty Orthopedics

Date 2015 Aug 1

PMID 26229875

Citations 5

Authors

Paulo Santoro Belangero

Mariana Ferreira Leal

Alberto de Castro Pochini

Carlos Vicente Andreoli

Benno Ejnisman

Moises Cohen

Affiliations

Soon will be listed here.

Abstract

Objective: To evaluate the expression of the genes COL1A1, COL1A2, COL3A1 and COL5A1 in the glenohumeral capsule of patients with traumatic anterior instability of the shoulder.

Methods: Samples from the glenohumeral capsule of 18 patients with traumatic anterior instability of the shoulder were evaluated. Male patients with a positive grip test and a Bankart lesion seen on magnetic resonance imaging were included. All the patients had suffered more than one episode of shoulder dislocation. Samples were collected from the injured glenohumeral capsule (anteroinferior region) and from the macroscopically unaffected region (anterosuperior region) of each patient. The expression of collagen genes was evaluated using the polymerase chain reaction after reverse transcription with quantitative analysis (qRT-PCR).

Results: The expression of COL1A1, COL1A2 and COL3A1 did not differ between the two regions of the shoulder capsule. However, it was observed that the expression of COL5A1 was significantly lower in the anteroinferior region than in the anterosuperior region (median ± interquartile range: 0.057 ± 0.052 vs. 0.155 ± 0.398; p = 0.028) of the glenohumeral capsule.

Conclusion: The affected region of the glenohumeral capsule in patients with shoulder instability presented reduced expression of COL5A1.

Citing Articles

[Research progress on pathological changes of glenohumeral capsule in patients with recurrent shoulder anterior dislocation].

Chen P, Liang D, Wu B, Li H, Liu H, Long Z Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2025; 39(2):243-249.

PMID: 39971372 PMC: 11839295. DOI: 10.7507/1002-1892.202408090.

Genetic Polymorphisms in gene and the Risk of Tendinopathy: Case-Control Study.

Lopes L, Matheus Guimaraes J, Amaral M, Pereira C, Wainchtock V, Goes R Rev Bras Ortop (Sao Paulo). 2023; 58(3):478-486.

PMID: 37396081 PMC: 10310418. DOI: 10.1055/s-0042-1757959.

Genetic Aspects in Shoulder Disorders.

Cohen C, Figueiredo E, Belangero P, Andreoli C, Leal M, Ejnisman B Rev Bras Ortop (Sao Paulo). 2020; 55(5):537-542.

PMID: 33093716 PMC: 7575388. DOI: 10.1055/s-0040-1702955.

The Epidemiology and Natural History of Anterior Shoulder Instability.

Galvin J, Ernat J, Waterman B, Stadecker M, Parada S Curr Rev Musculoskelet Med. 2017; 10(4):411-424.

PMID: 29038951 PMC: 5685954. DOI: 10.1007/s12178-017-9432-5.

Analysis of postoperative monitoring of patients undergoing shoulder arthroscopy for anterior instability.

Almeida A, Menegotto S, de Almeida N, Agostini A, Almeida L Rev Bras Ortop. 2017; 52(4):458-462.

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