Cyclooxygenase-2 and Ki67 Expression in Oral Leukoplakia: a Clinicopathological Study

Overview

Journal J Oral Maxillofac Res

Date 2015 Aug 1

PMID 26229582

Citations 4

Authors

Alper Sinanoglu

Merva Soluk-Tekkesin

Vakur Olgac

Affiliations

Soon will be listed here.

Abstract

Objectives: Oral leukoplakia is a precancerous lesion of the oral mucosa. The upregulation of Ki67 and cyclooxygenase-2 has been reported in both dysplastic and non-dysplastic tissues. The aim of this clinicopathological study was to investigate the prognostic value of Ki67 and cyclooxygenase-2 expression for oral leukoplakia.

Material And Methods: A total of 50 samples were investigated and the study group consisted of 30 oral leukoplakia samples. Samples of 10 intact oral mucosa and 10 squamous cell carcinoma were included as negative and positive control groups, respectively. Epithelial dysplasia was defined as oral intraepithelial neoplasia (OIN) and classified into subgroups 1 - 3. Tissue samples were assessed immunohistochemically for Ki67 and cyclooxygenase-2 expression. Clinicopathological correlations of oral leukoplakia patients were also investigated.

Results: All OIN 3 patients were non-smokers (P < 0.05), and homogeneous oral leukoplakia lesions also presented OIN. Both cyclooxygenase-2 and Ki67 expression increased with the severity of lesions, which defined different subgroups (P < 0.05), except there was no significant difference between the hyperkeratosis and OIN groups for Ki67 expression.

Conclusions: Cyclooxygenase-2 and Ki67 expression may have a prognostic value for the malignant transformation of oral leukoplakia.

Citing Articles

Importance of Ki-67 Labeling in Oral Leukoplakia with Features of Dysplasia and Carcinomatous Transformation: An Observational Study over 4 Years.

Mondal K, Mandal R, Sarkar B South Asian J Cancer. 2020; 9(2):99-104.

PMID: 33365288 PMC: 7752503. DOI: 10.1055/s-0040-1721212.

Mediators of Inflammation - A Potential Source of Biomarkers in Oral Squamous Cell Carcinoma.

Tampa M, Mitran M, Mitran C, Sarbu M, Matei C, Nicolae I J Immunol Res. 2018; 2018:1061780.

PMID: 30539028 PMC: 6260538. DOI: 10.1155/2018/1061780.

Pre-Cancerous Lesions in the Oral and Maxillofacial Region: A Literature Review with Special Focus on Etiopathogenesis.

Irani S Iran J Pathol. 2017; 11(4):303-322.

PMID: 28855922 PMC: 5563928.

A study of Ki-67 expression and its clinicopathological determinants in nondysplastic oral leukoplakia.

Mondal K, Mandal R, Sarkar B Contemp Clin Dent. 2016; 7(4):493-499.

PMID: 27994417 PMC: 5141664. DOI: 10.4103/0976-237X.194106.

References

Freitas M, Blanco-Carrion A, Gandara-Vila P, Antunez-Lopez J, Garcia-Garcia A, Gandara Rey J . Clinicopathologic aspects of oral leukoplakia in smokers and nonsmokers. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006; 102(2):199-203. DOI: 10.1016/j.tripleo.2005.12.009. View

Ho M, Risk J, Woolgar J, Field E, Field J, Steele J . The clinical determinants of malignant transformation in oral epithelial dysplasia. Oral Oncol. 2012; 48(10):969-976. DOI: 10.1016/j.oraloncology.2012.04.002. View

van der Waal I, Schepman K, van der Meij E, Smeele L . Oral leukoplakia: a clinicopathological review. Oral Oncol. 1998; 33(5):291-301. DOI: 10.1016/s1368-8375(97)00002-x. View

Amagasa T, Yamashiro M, Uzawa N . Oral premalignant lesions: from a clinical perspective. Int J Clin Oncol. 2011; 16(1):5-14. DOI: 10.1007/s10147-010-0157-3. View

de Vicente J, Fresno M, Lopez-Arranz J . Expression of cyclin D1 and Ki-67 in squamous cell carcinoma of the oral cavity: clinicopathological and prognostic significance. Oral Oncol. 2002; 38(3):301-8. DOI: 10.1016/s1368-8375(01)00060-4. View

Kovesi G, Szende B . Changes in apoptosis and mitotic index, p53 and Ki67 expression in various types of oral leukoplakia. Oncology. 2004; 65(4):331-6. DOI: 10.1159/000074646. View

Brouns E, Baart J, Bloemena E, Karagozoglu H, van der Waal I . The relevance of uniform reporting in oral leukoplakia: definition, certainty factor and staging based on experience with 275 patients. Med Oral Patol Oral Cir Bucal. 2012; 18(1):e19-26. PMC: 3548640. DOI: 10.4317/medoral.18756. View

Shibata M, Kodani I, Osaki M, Araki K, Adachi H, Ryoke K . Cyclo-oxygenase-1 and -2 expression in human oral mucosa, dysplasias and squamous cell carcinomas and their pathological significance. Oral Oncol. 2005; 41(3):304-12. DOI: 10.1016/j.oraloncology.2004.09.009. View

Schepman K, van der Meij E, Smeele L, van der Waal I . Malignant transformation of oral leukoplakia: a follow-up study of a hospital-based population of 166 patients with oral leukoplakia from The Netherlands. Oral Oncol. 1998; 34(4):270-5. View

10.

Johnson N . Tobacco use and oral cancer: a global perspective. J Dent Educ. 2001; 65(4):328-39. View

11.

Mohan S, Epstein J . Carcinogenesis and cyclooxygenase: the potential role of COX-2 inhibition in upper aerodigestive tract cancer. Oral Oncol. 2003; 39(6):537-46. DOI: 10.1016/s1368-8375(03)00035-6. View

12.

Lee J, Hung H, Cheng S, Chen Y, Chiang C, Liu B . Carcinoma and dysplasia in oral leukoplakias in Taiwan: prevalence and risk factors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006; 101(4):472-80. DOI: 10.1016/j.tripleo.2005.07.024. View

13.

Petti S, Scully C . Association between different alcoholic beverages and leukoplakia among non- to moderate-drinking adults: a matched case-control study. Eur J Cancer. 2006; 42(4):521-7. DOI: 10.1016/j.ejca.2005.07.038. View

14.

Sasaki K, Murakami T, Kawasaki M, Takahashi M . The cell cycle associated change of the Ki-67 reactive nuclear antigen expression. J Cell Physiol. 1987; 133(3):579-84. DOI: 10.1002/jcp.1041330321. View

15.

Itoh S, Matsui K, Furuta I, Takano Y . Immunohistochemical study on overexpression of cyclooxygenase-2 in squamous cell carcinoma of the oral cavity: its importance as a prognostic predictor. Oral Oncol. 2003; 39(8):829-35. DOI: 10.1016/s1368-8375(03)00105-2. View

16.

van der Waal I . Potentially malignant disorders of the oral and oropharyngeal mucosa; terminology, classification and present concepts of management. Oral Oncol. 2008; 45(4-5):317-23. DOI: 10.1016/j.oraloncology.2008.05.016. View

17.

Yu H, Xu S, Liu L, Shi L, Cai X, Lu W . Cyclooxygenase-2 expression in squamous dysplasia and squamous cell carcinoma of the esophagus. Cancer Lett. 2003; 198(2):193-201. DOI: 10.1016/s0304-3835(03)00340-9. View

18.

Jaber M, Porter S, Gilthorpe M, Bedi R, Scully C . Risk factors for oral epithelial dysplasia--the role of smoking and alcohol. Oral Oncol. 1999; 35(2):151-6. DOI: 10.1016/s1368-8375(98)00106-7. View

19.

Warnakulasuriya S, Johnson N, van der Waal I . Nomenclature and classification of potentially malignant disorders of the oral mucosa. J Oral Pathol Med. 2007; 36(10):575-80. DOI: 10.1111/j.1600-0714.2007.00582.x. View

20.

Lin D, Subbaramaiah K, Shah J, Dannenberg A, Boyle J . Cyclooxygenase-2: a novel molecular target for the prevention and treatment of head and neck cancer. Head Neck. 2002; 24(8):792-9. DOI: 10.1002/hed.10108. View