Increased Osteoblast Function in Vitro and in Vivo Through Surface Nanostructuring by Ultrasonic Shot Peening

Overview

Journal Int J Nanomedicine

Publisher Dove Medical Press

Specialty Biotechnology

Date 2015 Aug 1

PMID 26229463

Citations 4

Authors

Yongyuan Guo

Beibei Hu

Chu Tang

Yunpeng Wu

Pengfei Sun

Xianlong Zhang

Yuhua Jia

Affiliations

Soon will be listed here.

Abstract

Surface topography has significant influence on good and fast osseointegration of biomedical implants. In this work, ultrasonic shot peening was conducted to modify titanium to produce nanograined (NG) surface. Its ability to induce new bone formation was evaluated using an in vivo animal model. We demonstrated that the NG surface enhanced osteoblast adhesion, proliferation, differentiation, and mineralization in in vitro experiments compared to coarse-grained titanium surface. Push-out test, histological observations, fluorescent labeling, and histomorphometrical analysis consistently indicated that the NG surfaces developed have the higher osseointegration than coarse-grained surfaces. Those results suggest that ultrasonic shot peening has the potential for future use as a surface modification method in biomedical application.

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