» Articles » PMID: 26216850

Cyclic Dinucleotide-Controlled Regulatory Pathways in Streptomyces Species

Overview
Journal J Bacteriol
Specialty Microbiology
Date 2015 Jul 29
PMID 26216850
Citations 18
Authors
Affiliations
Soon will be listed here.
Abstract

The cyclic dinucleotides cyclic 3′,5′-diguanylate (c-di-GMP) and cyclic 3′,5′-diadenylate (c-di-AMP) have emerged as key components of bacterial signal transduction networks. These closely related second messengers follow the classical general principles of nucleotide signaling by integrating diverse signals into regulatory pathways that control cellular responses to changing environments. They impact distinct cellular processes, with c-di-GMP having an established role in promoting bacterial adhesion and inhibiting motility and c-di-AMP being involved in cell wall metabolism, potassium homeostasis, and DNA repair. The involvement of c-dinucleotides in the physiology of the filamentous, nonmotile streptomycetes remained obscure until recent discoveries showed that c-di-GMP controls the activity of the developmental master regulator BldD and that c-di-AMP determines the level of the resuscitation-promoting factor A(RpfA) cell wall-remodelling enzyme. Here, I summarize our current knowledge of c-dinucleotide signaling in Streptomyces species and highlight the important roles of c-di-GMP and c-di-AMP in the biology of these antibiotic-producing, multicellular bacteria.

Citing Articles

How c-di-GMP controls progression through the Streptomyces life cycle.

Gallagher K, Tschowri N, Brennan R, Schumacher M, Buttner M Curr Opin Microbiol. 2024; 80:102516.

PMID: 39059031 PMC: 11497840. DOI: 10.1016/j.mib.2024.102516.


The global regulation of c-di-GMP and cAMP in bacteria.

Liu C, Shi R, Jensen M, Zhu J, Liu J, Liu X mLife. 2024; 3(1):42-56.

PMID: 38827514 PMC: 11139211. DOI: 10.1002/mlf2.12104.


Nitric Oxide Signaling for Aerial Mycelium Formation in Streptomyces coelicolor A3(2) M145.

Honma S, Ito S, Yajima S, Sasaki Y Appl Environ Microbiol. 2022; 88(23):e0122222.

PMID: 36354316 PMC: 9746327. DOI: 10.1128/aem.01222-22.


Effect of toyF on wuyiencin and toyocamycin production by Streptomyces albulus CK-15.

Liu B, Wei Q, Yang M, Shi L, Zhang K, Ge B World J Microbiol Biotechnol. 2022; 38(4):65.

PMID: 35229201 DOI: 10.1007/s11274-022-03234-3.


Interplay between Non-Coding RNA Transcription, Stringent/Relaxed Phenotype and Antibiotic Production in .

Pinatel E, Calcagnile M, Tala A, Damiano F, Siculella L, Peano C Antibiotics (Basel). 2021; 10(8).

PMID: 34438997 PMC: 8388888. DOI: 10.3390/antibiotics10080947.


References
1.
Fazli M, OConnell A, Nilsson M, Niehaus K, Dow J, Givskov M . The CRP/FNR family protein Bcam1349 is a c-di-GMP effector that regulates biofilm formation in the respiratory pathogen Burkholderia cenocepacia. Mol Microbiol. 2011; 82(2):327-41. DOI: 10.1111/j.1365-2958.2011.07814.x. View

2.
Srivastava D, Harris R, Waters C . Integration of cyclic di-GMP and quorum sensing in the control of vpsT and aphA in Vibrio cholerae. J Bacteriol. 2011; 193(22):6331-41. PMC: 3209240. DOI: 10.1128/JB.05167-11. View

3.
McCormick J, Flardh K . Signals and regulators that govern Streptomyces development. FEMS Microbiol Rev. 2011; 36(1):206-31. PMC: 3285474. DOI: 10.1111/j.1574-6976.2011.00317.x. View

4.
Luo Y, Helmann J . Analysis of the role of Bacillus subtilis σ(M) in β-lactam resistance reveals an essential role for c-di-AMP in peptidoglycan homeostasis. Mol Microbiol. 2012; 83(3):623-39. PMC: 3306796. DOI: 10.1111/j.1365-2958.2011.07953.x. View

5.
Davies B, Bogard R, Young T, Mekalanos J . Coordinated regulation of accessory genetic elements produces cyclic di-nucleotides for V. cholerae virulence. Cell. 2012; 149(2):358-70. PMC: 3620040. DOI: 10.1016/j.cell.2012.01.053. View