Mycobacterium Ulcerans Dynamics in Aquatic Ecosystems Are Driven by a Complex Interplay of Abiotic and Biotic Factors

Overview

Journal Elife

Specialty Biology

Date 2015 Jul 29

PMID 26216042

Citations 20

Authors

Andres Garchitorena

Jean-Francois Guegan

Lucas Leger

Sara Eyangoh

Laurent Marsollier

Benjamin Roche

Affiliations

Soon will be listed here.

Abstract

Host-parasite interactions are often embedded within complex host communities and can be influenced by a variety of environmental factors, such as seasonal variations in climate or abiotic conditions in water and soil, which confounds our understanding of the main drivers of many multi-host pathogens. Here, we take advantage of a combination of large environmental data sets on Mycobacterium ulcerans (MU), an environmentally persistent microorganism associated to freshwater ecosystems and present in a large variety of aquatic hosts, to characterize abiotic and biotic factors driving the dynamics of this pathogen in two regions of Cameroon. We find that MU dynamics are largely driven by seasonal climatic factors and certain physico-chemical conditions in stagnant and slow-flowing ecosystems, with an important role of pH as limiting factor. Furthermore, water conditions can modify the effect of abundance and diversity of aquatic organisms on MU dynamics, which suggests a different contribution of two MU transmission routes for aquatic hosts (trophic vs environmental transmission) depending on local abiotic factors.

Citing Articles

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