Coding the Direct/indirect Pathways by D1 and D2 Receptors is Not Valid for Accumbens Projections

Overview

Journal Nat Neurosci

Date 2015 Jul 28

PMID 26214370

Citations 238

Authors

Yonatan M Kupchik

Robyn M Brown

Jasper A Heinsbroek

Mary Kay Lobo

Danielle J Schwartz

Peter W Kalivas

Affiliations

Soon will be listed here.

Abstract

It is widely accepted that D1 dopamine receptor-expressing striatal neurons convey their information directly to the output nuclei of the basal ganglia, whereas D2-expressing neurons do so indirectly via pallidal neurons. Combining optogenetics and electrophysiology, we found that this architecture does not apply to mouse nucleus accumbens projections to the ventral pallidum. Thus, current thinking attributing D1 and D2 selectivity to accumbens projections akin to dorsal striatal pathways needs to be reconsidered.

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