NOP14 Suppresses Breast Cancer Progression by Inhibiting NRIP1/Wnt/β-catenin Pathway

Overview

Journal Oncotarget

Specialty Oncology

Date 2015 Jul 28

PMID 26213846

Citations 19

Authors

Jin-Ju Lei

Rou-Jun Peng

Bo-Hua Kuang

Zhong-Yu Yuan

Tao Qin

Wen-Sheng Liu

Yun-Miao Guo

Hui-Qiong Han

Yi-Fan Lian

Cheng-Cheng Deng

Hao-Jiong Zhang

Li-Zhen Chen

Qi-Sheng Feng

Miao Xu

Lin Feng

Jin-Xin Bei

Yi-Xin Zeng

Affiliations

Soon will be listed here.

Abstract

NOP14, which is functionally conserved among eukaryotes, has been implicated in cancer development. Here, we show that NOP14 is poorly expressed in breast cancer cells and invasive breast cancer tissues. In vivo and in vitro studies indicated that NOP14 suppressed the tumorigenesis and metastasis of breast cancer cells. Further investigations revealed that NOP14 enhanced ERα expression and inhibited the Wnt/β-catenin pathway by up-regulating NRIP1 expression. Survival analysis indicated that low NOP14 expression was significantly associated with poor overall survival (P = 0.0006) and disease-free survival (P = 0.0007), suggesting that NOP14 is a potential prognostic factor in breast cancer. Taken together, our findings reveal that NOP14 may suppress breast cancer progression and provide new insights into the development of targeted therapeutic agents for breast cancer.

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