The Role of MicroRNAs in Bone Remodeling

Overview

Journal Int J Oral Sci

Date 2015 Jul 25

PMID 26208037

Citations 52

Authors

Dian Jing

Jin Hao

Yu Shen

Ge Tang

Mei-Le Li

Shi-Hu Huang

Zhi-He Zhao

Affiliations

Soon will be listed here.

Abstract

Bone remodeling is balanced by bone formation and bone resorption as well as by alterations in the quantities and functions of seed cells, leading to either the maintenance or deterioration of bone status. The existing evidence indicates that microRNAs (miRNAs), known as a family of short non-coding RNAs, are the key post-transcriptional repressors of gene expression, and growing numbers of novel miRNAs have been verified to play vital roles in the regulation of osteogenesis, osteoclastogenesis, and adipogenesis, revealing how they interact with signaling molecules to control these processes. This review summarizes the current knowledge of the roles of miRNAs in regulating bone remodeling as well as novel applications for miRNAs in biomaterials for therapeutic purposes.

Citing Articles

Molecular Signaling Pathways and MicroRNAs in Bone Remodeling: A Narrative Review.

Singh M, Singh P, Singh B, Sharma K, Kumar N, Singh D Diseases. 2024; 12(10).

PMID: 39452495 PMC: 11507001. DOI: 10.3390/diseases12100252.

MicroRNAs and their Modulatory Effect on the Hallmarks of Osteosarcopenia.

Silva W, Cruz A, Duque G Curr Osteoporos Rep. 2024; 22(5):458-470.

PMID: 39162945 DOI: 10.1007/s11914-024-00880-4.

The Involvement of microRNAs in Bone Remodeling Signaling Pathways and Their Role in the Development of Osteoporosis.

Jimenez-Ortega R, Ortega-Melendez A, Patino N, Rivera-Paredez B, Hidalgo-Bravo A, Velazquez-Cruz R Biology (Basel). 2024; 13(7).

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Identification of the miRNA-mRNA regulatory network in a mouse model of early fracture.

Wang M, Xie Z, Yan K, Qiao C, Yan S, Wu G Front Genet. 2024; 15:1408404.

PMID: 38919952 PMC: 11196604. DOI: 10.3389/fgene.2024.1408404.

Identification of circulating miRNAs as fracture-related biomarkers.

Della Bella E, Menzel U, Naros A, Kubosch E, Alini M, Stoddart M PLoS One. 2024; 19(5):e0303035.

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