Near-infrared Spectroscopy Integrated Catheter for Characterization of Myocardial Tissues: Preliminary Demonstrations to Radiofrequency Ablation Therapy for Atrial Fibrillation

Overview

Journal Biomed Opt Express

Specialty Radiology

Date 2015 Jul 24

PMID 26203376

Citations 24

Authors

Rajinder P Singh-Moon

Charles C Marboe

Christine P Hendon

Affiliations

Soon will be listed here.

Abstract

Effects of radiofrequency ablation (RFA) treatment of atrial fibrillation can be limited by the ability to characterize the tissue in contact. Parameters obtained by conventional catheters, such as impedance and temperature can be insufficient in providing physiological information pertaining to effective treatment. In this report, we present a near-infrared spectroscopy (NIRS)-integrated catheter capable of extracting tissue optical properties. Validation experiments were first performed in tissue phantoms with known optical properties. We then apply the technique for characterization of myocardial tissues in swine and human hearts, ex vivo. Additionally, we demonstrate the recovery of critical parameters relevant to RFA therapy including contact verification, and lesion transmurality. These findings support the application of NIRS for improved guidance in RFA therapeutic interventions.

Citing Articles

Robust, high-density lesion mapping in the left atrium with near-infrared spectroscopy.

Yang H, Majumder J, Huang Z, Saluja D, Laurita K, Rollins A J Biomed Opt. 2024; 29(2):028001.

PMID: 38419756 PMC: 10901242. DOI: 10.1117/1.JBO.29.2.028001.

Niche preclinical and clinical applications of photoacoustic imaging with endogenous contrast.

John S, Hester S, Basij M, Paul A, Xavierselvan M, Mehrmohammadi M Photoacoustics. 2023; 32:100533.

PMID: 37636547 PMC: 10448345. DOI: 10.1016/j.pacs.2023.100533.

Monitoring of irrigated lesion formation with single fiber based multispectral system using machine learning.

Park S, Singh-Moon R, Yang H, Hendon C J Biophotonics. 2022; 15(9):e202100374.

PMID: 35666015 PMC: 9452461. DOI: 10.1002/jbio.202100374.

Cardiac endocardial left atrial substrate and lesion depth mapping using near-infrared spectroscopy.

Park S, Yang H, Marboe C, Ziv O, Laurita K, Rollins A Biomed Opt Express. 2022; 13(4):1801-1819.

PMID: 35519253 PMC: 9045901. DOI: 10.1364/BOE.451547.

A Novel Laser Energy Ablation Catheter for Endocardial Cavo-Tricuspid Isthmus Ablation and Epicardial Ventricular Lesion Formation: An Proof-of-Concept Study.

Krist D, Linz D, Schotten U, Zeemering S, Leenen D Front Med Technol. 2022; 4:834856.

PMID: 35387364 PMC: 8979165. DOI: 10.3389/fmedt.2022.834856.

References

Reif R, Aamar O, Bigio I . Analytical model of light reflectance for extraction of the optical properties in small volumes of turbid media. Appl Opt. 2007; 46(29):7317-28. DOI: 10.1364/ao.46.007317. View

Schaub M, Hirzel H . Atrial and ventricular isomyosin composition in patients with different forms of cardiac hypertrophy. Basic Res Cardiol. 1987; 82 Suppl 2:357-67. DOI: 10.1007/978-3-662-11289-2_35. View

Jacques S . Optical properties of biological tissues: a review. Phys Med Biol. 2013; 58(11):R37-61. DOI: 10.1088/0031-9155/58/11/R37. View

Charnock J, Dryden W, McMurchie E, Abeywardena M, Russell G . Differences in the fatty acid composition of atrial and ventricular phospholipids of rat heart following standard and lipid-supplemented diets. Comp Biochem Physiol B. 1983; 75(1):47-52. DOI: 10.1016/0305-0491(83)90038-x. View

Legato M . Ultrastructure of the atrial, ventricular, and Purkinje cell, with special reference to the genesis of arrhythmias. Circulation. 1973; 47(1):178-89. DOI: 10.1161/01.cir.47.1.178. View

Tan H, Wang X, Shi H, Zhou L, Gu J, Liu X . Left atrial wall thickness: anatomic aspects relevant to catheter ablation of atrial fibrillation. Chin Med J (Engl). 2012; 125(1):12-5. View

Ouyang F, Antz M, Ernst S, Hachiya H, Mavrakis H, Deger F . Recovered pulmonary vein conduction as a dominant factor for recurrent atrial tachyarrhythmias after complete circular isolation of the pulmonary veins: lessons from double Lasso technique. Circulation. 2004; 111(2):127-35. DOI: 10.1161/01.CIR.0000151289.73085.36. View

Wood M . Exposing gaps in linear radiofrequency lesions: form before function. Circ Arrhythm Electrophysiol. 2011; 4(3):257-9. DOI: 10.1161/CIRCEP.111.963033. View

Reif R, Amorosino M, Calabro K, Aamar O, Singh S, Bigio I . Analysis of changes in reflectance measurements on biological tissues subjected to different probe pressures. J Biomed Opt. 2008; 13(1):010502. DOI: 10.1117/1.2870115. View

10.

Derbyshire G, Bogen D, Unger M . Thermally induced optical property changes in myocardium at 1.06 microns. Lasers Surg Med. 1990; 10(1):28-34. DOI: 10.1002/lsm.1900100108. View

11.

Gan Y, Fleming C . Extracting three-dimensional orientation and tractography of myofibers using optical coherence tomography. Biomed Opt Express. 2013; 4(10):2150-65. PMC: 3799673. DOI: 10.1364/BOE.4.002150. View

12.

Taroni P, Bassi A, Comelli D, Farina A, Cubeddu R, Pifferi A . Diffuse optical spectroscopy of breast tissue extended to 1100 nm. J Biomed Opt. 2009; 14(5):054030. DOI: 10.1117/1.3251051. View

13.

dAvila A, Houghtaling C, Gutierrez P, Vragovic O, Ruskin J, Josephson M . Catheter ablation of ventricular epicardial tissue: a comparison of standard and cooled-tip radiofrequency energy. Circulation. 2004; 109(19):2363-9. DOI: 10.1161/01.CIR.0000128039.87485.0B. View

14.

BOWEN W . The absorption spectra and extinction coefficients of myoglobin. J Biol Chem. 1949; 179(1):235-45. View

15.

Fleming C, Quan K, Rollins A . Toward guidance of epicardial cardiac radiofrequency ablation therapy using optical coherence tomography. J Biomed Opt. 2010; 15(4):041510. PMC: 2912935. DOI: 10.1117/1.3449569. View

16.

Singh-Moon R, Roblyer D, Bigio I, Joshi S . Spatial mapping of drug delivery to brain tissue using hyperspectral spatial frequency-domain imaging. J Biomed Opt. 2014; 19(9):96003. PMC: 4157604. DOI: 10.1117/1.JBO.19.9.096003. View

17.

Wazni O, Marrouche N, Martin D, Verma A, Bhargava M, Saliba W . Radiofrequency ablation vs antiarrhythmic drugs as first-line treatment of symptomatic atrial fibrillation: a randomized trial. JAMA. 2005; 293(21):2634-40. DOI: 10.1001/jama.293.21.2634. View

18.

Bosman S . Heat-induced structural alterations in myocardium in relation to changing optical properties. Appl Opt. 2010; 32(4):461-3. DOI: 10.1364/AO.32.000461. View

19.

Go A, Mozaffarian D, Roger V, Benjamin E, Berry J, Blaha M . Heart disease and stroke statistics--2014 update: a report from the American Heart Association. Circulation. 2013; 129(3):e28-e292. PMC: 5408159. DOI: 10.1161/01.cir.0000441139.02102.80. View

20.

Pickering J, Bosman S, Posthumus P, Blokland P, Beek J, van Gemert M . Changes in the optical properties (at 632.8 nm) of slowly heated myocardium. Appl Opt. 2010; 32(4):367-71. DOI: 10.1364/AO.32.000367. View