Lung Cancer: Developments, Concepts, and Specific Aspects of the New WHO Classification

Overview

Journal J Cancer Res Clin Oncol

Specialty Oncology

Date 2015 Jul 23

PMID 26197868

Citations 26

Authors

Iver Petersen

Arne Warth

Affiliations

Soon will be listed here.

Abstract

Introduction: Diagnostic methods and algorithms for the diagnosis of pulmonary neoplasms have considerably changed over the recent years. Based on large-scale molecular characterization studies and the development of targeted therapies, precise morphological, immunohistochemical, and molecular pathological tumor subtyping is now of utmost importance for evidence-based treatment decisions. Changes of diagnostic concepts initially referred to biopsies and cytology specimens but are now also transferred to resection specimens.

Methods: This review is focused on recent developments in morphological and immunohistochemical subtyping of pulmonary neoplasms and concepts of tumor progression. It also provides perspectives on relevant changes of diagnostic concepts within the context of the new WHO classification.

Conclusion: It becomes apparent that a three-step diagnostic concept based on morphology, immunohistochemistry, and molecular pathology is important to meet the requirements of an increasingly more complex, interdisciplinary care of lung cancer patients and to allow for reliable, clinically meaningful tumor diagnoses.

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References

Warth A, Stenzinger A, Weichert W . [Novel morphological and molecular aspects of lung cancer]. Pathologe. 2013; 34(5):419-28. DOI: 10.1007/s00292-013-1787-9. View

Warth A, Cortis J, Fink L, Fisseler-Eckhoff A, Geddert H, Hager T . Training increases concordance in classifying pulmonary adenocarcinomas according to the novel IASLC/ATS/ERS classification. Virchows Arch. 2012; 461(2):185-93. DOI: 10.1007/s00428-012-1263-6. View

Brambilla E, Moro D, Veale D, Brichon P, Stoebner P, PARAMELLE B . Basal cell (basaloid) carcinoma of the lung: a new morphologic and phenotypic entity with separate prognostic significance. Hum Pathol. 1992; 23(9):993-1003. DOI: 10.1016/0046-8177(92)90260-a. View

Janssen-Heijnen M, Coebergh J . Trends in incidence and prognosis of the histological subtypes of lung cancer in North America, Australia, New Zealand and Europe. Lung Cancer. 2001; 31(2-3):123-37. DOI: 10.1016/s0169-5002(00)00197-5. View

Li Y, Linnoila R . Multidirectional differentiation of Achaete-Scute homologue-1-defined progenitors in lung development and injury repair. Am J Respir Cell Mol Biol. 2012; 47(6):768-75. PMC: 3547090. DOI: 10.1165/rcmb.2012-0027OC. View

Warth A, Muley T, Meister M, Stenzinger A, Thomas M, Schirmacher P . The novel histologic International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification system of lung adenocarcinoma is a stage-independent predictor of survival. J Clin Oncol. 2012; 30(13):1438-46. DOI: 10.1200/JCO.2011.37.2185. View

Travis W, Brambilla E, Burke A, Marx A, Nicholson A . Introduction to The 2015 World Health Organization Classification of Tumors of the Lung, Pleura, Thymus, and Heart. J Thorac Oncol. 2015; 10(9):1240-1242. DOI: 10.1097/JTO.0000000000000663. View

Peifer M, Fernandez-Cuesta L, Sos M, George J, Seidel D, Kasper L . Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Nat Genet. 2012; 44(10):1104-10. PMC: 4915822. DOI: 10.1038/ng.2396. View

Kadota K, Yeh Y, Sima C, Rusch V, Moreira A, Adusumilli P . The cribriform pattern identifies a subset of acinar predominant tumors with poor prognosis in patients with stage I lung adenocarcinoma: a conceptual proposal to classify cribriform predominant tumors as a distinct histologic subtype. Mod Pathol. 2013; 27(5):690-700. PMC: 4374572. DOI: 10.1038/modpathol.2013.188. View

10.

Linnoila R . Functional facets of the pulmonary neuroendocrine system. Lab Invest. 2006; 86(5):425-44. DOI: 10.1038/labinvest.3700412. View

11.

Yilmazbayhan D, Esberk Ates L, Dilege S, Gulluoglu M, Tanju S, Kalayci G . Pulmonary large cell carcinoma with rhabdoid phenotype. Ann Diagn Pathol. 2005; 9(4):223-6. DOI: 10.1016/j.anndiagpath.2005.04.011. View

12.

Chetty R, Bhana B, Batitang S, Govender D . Lung carcinomas composed of rhabdoid cells. Eur J Surg Oncol. 1997; 23(5):432-4. DOI: 10.1016/s0748-7983(97)93725-2. View

13.

Stelow E . A review of NUT midline carcinoma. Head Neck Pathol. 2011; 5(1):31-5. PMC: 3037455. DOI: 10.1007/s12105-010-0235-x. View

14.

Cavazza A, Colby T, Tsokos M, Rush W, Travis W . Lung tumors with a rhabdoid phenotype. Am J Clin Pathol. 1996; 105(2):182-8. DOI: 10.1093/ajcp/105.2.182. View

15.

Moreira A, Joubert P, Downey R, Rekhtman N . Cribriform and fused glands are patterns of high-grade pulmonary adenocarcinoma. Hum Pathol. 2014; 45(2):213-20. DOI: 10.1016/j.humpath.2013.10.011. View

16.

Weichert W, Warth A . Early lung cancer with lepidic pattern: adenocarcinoma in situ, minimally invasive adenocarcinoma, and lepidic predominant adenocarcinoma. Curr Opin Pulm Med. 2014; 20(4):309-16. DOI: 10.1097/MCP.0000000000000065. View

17.

Kadota K, Nitadori J, Sima C, Ujiie H, Rizk N, Jones D . Tumor Spread through Air Spaces is an Important Pattern of Invasion and Impacts the Frequency and Location of Recurrences after Limited Resection for Small Stage I Lung Adenocarcinomas. J Thorac Oncol. 2015; 10(5):806-814. PMC: 4500042. DOI: 10.1097/JTO.0000000000000486. View

18.

Warth A, Muley T, Kossakowski C, Stenzinger A, Schirmacher P, Dienemann H . Prognostic impact and clinicopathological correlations of the cribriform pattern in pulmonary adenocarcinoma. J Thorac Oncol. 2015; 10(4):638-44. DOI: 10.1097/JTO.0000000000000490. View

19.

Warth A, Stenzinger A, von Brunneck A, Goeppert B, Cortis J, Petersen I . Interobserver variability in the application of the novel IASLC/ATS/ERS classification for pulmonary adenocarcinomas. Eur Respir J. 2012; 40(5):1221-7. DOI: 10.1183/09031936.00219211. View

20.

Bubendorf L . [Preneoplastic lesions of pulmonary carcinoma]. Pathologe. 2011; 32 Suppl 2:218-23. DOI: 10.1007/s00292-011-1527-y. View