Testosterone and Adult Male Bone: Actions Independent of 5α-Reductase and Aromatase

Overview

Journal Exerc Sport Sci Rev

Specialty Orthopedics

Date 2015 Jul 22

PMID 26196865

Citations 14

Authors

Joshua F Yarrow

Thomas J Wronski

Stephen E Borst

Affiliations

Soon will be listed here.

Abstract

Androgens and estrogens influence skeletal development and maintenance in males. However, the relative contributions of the circulating sex steroid hormones that originate from testicular/adrenal secretion versus those produced locally in bone via intracrine action require further elucidation. Our novel hypothesis is that testosterone exerts direct protective effects on the adult male skeleton independently of the actions of 5α-reductase or aromatase.

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