Article: [Acute non-allergic angioedema. Rare cause for intensive care unit admission]

Angiotensin-converting enzyme (ACE) inhibitor-induced angioedema usually follows an uneventful clinical course; however, if upper airway structures are involved, life-threatening complications may develop. Thus, affected patients should be carefully monitored in an intensive care unit and, if need be, the airway has to be secured early on. This case report discusses diagnostic and therapeutic approaches in a patient with suspected ACE inhibitor-induced angioedema, who had initially been admitted for neoadjuvant radiochemotherapy of rectal cancer.

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References

1.

Bas M, Greve J, Stelter K, Havel M, Strassen U, Rotter N . A randomized trial of icatibant in ACE-inhibitor-induced angioedema. N Engl J Med. 2015; 372(5):418-25. DOI: 10.1056/NEJMoa1312524. View

2.

Bezalel S, Mahlab-Guri K, Asher I, Werner B, Sthoeger Z . Angiotensin-converting enzyme inhibitor-induced angioedema. Am J Med. 2014; 128(2):120-5. DOI: 10.1016/j.amjmed.2014.07.011. View

3.

Stojiljkovic L . Renin-angiotensin system inhibitors and angioedema: anesthetic implications. Curr Opin Anaesthesiol. 2012; 25(3):356-62. DOI: 10.1097/ACO.0b013e328352dda5. View

4.

Lewis L . Angioedema: etiology, pathophysiology, current and emerging therapies. J Emerg Med. 2013; 45(5):789-96. DOI: 10.1016/j.jemermed.2013.03.045. View

5.

Rasmussen E, Mey K, Bygum A . Angiotensin-converting enzyme inhibitor-induced angioedema--a dangerous new epidemic. Acta Derm Venereol. 2013; 94(3):260-4. DOI: 10.2340/00015555-1760. View

6.

Wilkerson R . Angioedema in the emergency department: an evidence-based review. Emerg Med Pract. 2012; 14(11):1-21. View

7.

Makani H, Messerli F, Romero J, Wever-Pinzon O, Korniyenko A, Sevilla Berrios R . Meta-analysis of randomized trials of angioedema as an adverse event of renin-angiotensin system inhibitors. Am J Cardiol. 2012; 110(3):383-91. DOI: 10.1016/j.amjcard.2012.03.034. View

8.

Bas M, Greve J, Stelter K, Bier H, Stark T, Hoffmann T . Therapeutic efficacy of icatibant in angioedema induced by angiotensin-converting enzyme inhibitors: a case series. Ann Emerg Med. 2010; 56(3):278-82. DOI: 10.1016/j.annemergmed.2010.03.032. View

9.

Jaiganesh T, Wiese M, Hollingsworth J, Hughan C, Kamara M, Wood P . Acute angioedema: recognition and management in the emergency department. Eur J Emerg Med. 2012; 20(1):10-7. DOI: 10.1097/MEJ.0b013e328356f76e. View

10.

Kim S, Brooks J, Sheikh J, Kaplan M, Goldberg B . Angioedema deaths in the United States, 1979-2010. Ann Allergy Asthma Immunol. 2014; 113(6):630-4. DOI: 10.1016/j.anai.2014.09.003. View

11.

Hoover T, Lippmann M, Grouzmann E, MARCEAU F, Herscu P . Angiotensin converting enzyme inhibitor induced angio-oedema: a review of the pathophysiology and risk factors. Clin Exp Allergy. 2009; 40(1):50-61. DOI: 10.1111/j.1365-2222.2009.03323.x. View

[Acute Non-allergic Angioedema. Rare Cause for Intensive Care Unit Admission]