Diagnostic Model of Saliva Peptide Finger Print Analysis of Oral Squamous Cell Carcinoma Patients Using Weak Cation Exchange Magnetic Beads

Overview

Journal Biosci Rep

Specialty Cell Biology

Date 2015 Jul 17

PMID 26182373

Citations 8

Authors

Wei-Peng Jiang

Zhen Wang

Li-Xin Xu

Xin Peng

Feng Chen

Affiliations

Soon will be listed here.

Abstract

Saliva diagnostics utilizing nanotechnology and molecular technologies to detect oral squamous cell carcinoma (OSCC) has become an attractive field of study. However, no specific methods have been established. To refine the diagnostic power of saliva peptide fingerprints for the early detection of OSCC, we screened the expression spectrum of salivary peptides in 40 T1 stage OSCC patients (and healthy controls) using MALDI-TOF-MS combined with magnetic beads. Fifty proteins showed significantly different expression levels in the OSCC samples (P<0.05). Potential biomarkers were also predicted. The novel diagnostic proteomic model with m/z peaks of 1285.6 Da and 1432.2 Da are of certain value for early diagnosis of OSCC.

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