Cordyceps Sinensis Attenuates Renal Fibrosis and Suppresses BAG3 Induction in Obstructed Rat Kidney

Overview

Journal Am J Transl Res

Specialty General Medicine

Date 2015 Jul 16

PMID 26175854

Citations 10

Authors

Feng Du

Si Li

Tian Wang

Hai-Yan Zhang

Zhi-Hong Zong

Zhen-Xian Du

De-Tian Li

Hua-Qin Wang

Bo Liu

Jia-Ning Miao

Xiao-Hui Bian

Affiliations

Soon will be listed here.

Abstract

BAG3 regulates a number of cellular processes, including cell proliferation, apoptosis, adhesion and migration, and epithelial-mesenchymal transition (EMT). However, the role of BAG3 in renal tubular EMT and renal interstitial fibrosis remains elusive. This study aimed to examine the dynamic expression of BAG3 during renal fibrosis, and to investigate the efficacy of Cordyceps sinensis (C. sinensis) on renal fibrosis. A rat model of unilateral ureteral obstruction (UUO) was established, and the expression of BAG3 and α-SMA, and the efficacy of C. sinensis on renal fibrosis induced by UUO were examined. The results showed that UUO led to collagen accumulation, which was significantly suppressed by C. sinensis. UUO increased the expression of BAG3 and α-SMA, a mesenchymal marker, while UUO induced BAG3 and α-SMA expression was significantly inhibited by C. sinensis. In addition, immunohistochemical staining demonstrated that BAG3 immunoreactivity was restricted to tubular epithelium. In conclusion, BAG3 is a potential target for the prevention and/or treatment of renal fibrosis, and C. Sinensis is a promising agent for renal fibrosis.

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