» Articles » PMID: 26175085

Functional Salivary Gland Regeneration As the Next Generation of Organ Replacement Regenerative Therapy

Overview
Journal Odontology
Specialty Dentistry
Date 2015 Jul 16
PMID 26175085
Citations 8
Authors
Affiliations
Soon will be listed here.
Abstract

Oral health is maintained by the coordinated function of many organs including the teeth and salivary glands. Dysfunction of these organs causes many problems, such as dental caries, swallowing dysfunction and periodontal disease. Regenerative therapy for salivary gland tissue repair and whole-salivary gland replacement is currently considered a novel therapeutic concept that may have potential for the full recovery of salivary gland function. Salivary gland tissue stem cells are thought to be candidate cell sources for salivary gland tissue repair therapies. In addition, whole-salivary gland replacement therapy may become a novel next-generation organ regenerative therapy. Almost all organs arise from reciprocal epithelial and mesenchymal interactions of the germ layers. We developed a novel bioengineering method, an organ germ method that can reproduce organogenesis through the epithelial-mesenchymal interaction. A bioengineered salivary gland germ can regenerate a structurally correct salivary gland in vitro, and bioengineered salivary glands successfully secrete saliva into the oral cavity from ducts in the recipient through the reestablishment of the afferent-efferent neural network. The bioengineered salivary gland can also improve the symptoms of xerostomia, such as bacterial infection and swallowing dysfunction. In this review, we describe recent findings and technological developments of salivary gland regenerative therapy.

Citing Articles

The Prevalence of Xerostomia in Older Thai Individuals with Type II Diabetes Mellitus and Its Association with Type of Toothpaste and Oral Functions: A Cross-Sectional Study Using Questionnaires.

Sonpanao P, Janebodin K, Namvichaisirikul N, Thongjit S, Jitprasertwong P Geriatrics (Basel). 2023; 8(4).

PMID: 37489324 PMC: 10366830. DOI: 10.3390/geriatrics8040076.


Newer approaches to dry eye therapy: Nanotechnology, regenerative medicine, and tissue engineering.

Joshi V, Singh S, Thacker M, Pati F, Vemuganti G, Basu S Indian J Ophthalmol. 2023; 71(4):1292-1303.

PMID: 37026261 PMC: 10276749. DOI: 10.4103/IJO.IJO_2806_22.


Recent update on craniofacial tissue engineering.

Emara A, Shah R J Tissue Eng. 2021; 12:20417314211003735.

PMID: 33959245 PMC: 8060749. DOI: 10.1177/20417314211003735.


Comparison of Prostate-Specific Membrane Antigen Expression Levels in Human Salivary Glands to Non-Human Primates and Rodents.

Roy J, Warner B, Basuli F, Zhang X, Wong K, Pranzatelli T Cancer Biother Radiopharm. 2020; 35(4):284-291.

PMID: 32074455 PMC: 7247045. DOI: 10.1089/cbr.2019.3079.


First-in-man intraglandular implantation of stromal vascular fraction and adipose-derived stem cells plus platelet-rich plasma in irradiation-induced gland damage: a case study.

Comella K, Bell W Int Med Case Rep J. 2017; 10:295-299.

PMID: 28860871 PMC: 5566327. DOI: 10.2147/IMCRJ.S142514.


References
1.
Ogawa M, Yamashita K, Niikura M, Nakajima K, Toyoshima K, Oshima M . Saliva secretion in engrafted mouse bioengineered salivary glands using taste stimulation. J Prosthodont Res. 2014; 58(1):17-25. DOI: 10.1016/j.jpor.2013.12.001. View

2.
Zhang Y, Guo C, Zhang L, Wang Y, Peng X, Mao C . Prevention of radiation-induced xerostomia by submandibular gland transfer. Head Neck. 2011; 34(7):937-42. DOI: 10.1002/hed.21859. View

3.
Ishida K, Murofushi M, Nakao K, Morita R, Ogawa M, Tsuji T . The regulation of tooth morphogenesis is associated with epithelial cell proliferation and the expression of Sonic hedgehog through epithelial-mesenchymal interactions. Biochem Biophys Res Commun. 2011; 405(3):455-61. DOI: 10.1016/j.bbrc.2011.01.052. View

4.
Kagami H, Wang S, Hai B . Restoring the function of salivary glands. Oral Dis. 2008; 14(1):15-24. DOI: 10.1111/j.1601-0825.2006.01339.x. View

5.
Takahashi S, Schoch E, Walker N . Origin of acinar cell regeneration after atrophy of the rat parotid induced by duct obstruction. Int J Exp Pathol. 1999; 79(5):293-301. PMC: 3220221. DOI: 10.1046/j.1365-2613.1998.710405.x. View