Left Ventricular Global Function Index Assessed by Cardiovascular Magnetic Resonance for the Prediction of Cardiovascular Events in ST-elevation Myocardial Infarction

Overview

Journal J Cardiovasc Magn Reson

Publisher Elsevier

Specialties Cardiology & Vascular Diseases
Radiology

Date 2015 Jul 16

PMID 26174798

Citations 18

Authors

Ingo Eitel

J Poss

A Jobs

C Eitel

S de Waha

J Barkhausen

S Desch

H Thiele

Affiliations

Soon will be listed here.

Abstract

Background: The left ventricular performance index (LVGFI) as a comprehensive marker of cardiac performance integrates LV structure with global function within one index. In a prospective cohort study of healthy individuals the LVGFI demonstrated a superior prognostic value as compared to LV ejection fraction (LVEF). In patients after ST-segment elevation myocardial infarction (STEMI), however, the role of the LVGFI is unknown. Aim of this study was to investigate the relationship between the LVGFI and infarct characteristics as well as prognosis in a large multicenter STEMI population.

Methods: In total 795 STEMI patients reperfused by primary angioplasty (<12 h after symptom onset) underwent cardiovascular magnetic resonance (CMR) at 8 centers. CMR was completed within one week after infarction using a standardized protocol including LV dimensions, mass and function for calculation of the LVGFI. The primary clinical endpoint of the study was the occurrence of major adverse cardiac events (MACE).

Results: The median LVGFI was 31.2 % (interquartile range 25.7 to 36.6). Patients with LVGFI < median had significantly larger infarcts, less myocardial salvage, a larger extent of microvascular obstruction, higher incidence of intramyocardial hemorrhage and more pronounced LV dysfunction (p < 0.001 for all). MACE and mortality rates were significantly higher in the LVGFI < median group (p < 0.001 and p = 0.003, respectively). The LVGFI had an incremental prognostic value in addition to LVEF for prediction of all-cause mortality.

Conclusions: The LVGFI strongly correlates with markers of severe myocardial and microvascular damage in patients with STEMI, offering prognostic information beyond traditional cardiac risk factors including the LVEF.

Trials Registration: ClinicalTrials.gov: NCT00712101.

Citing Articles

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PMID: 36637709 DOI: 10.1007/s10554-023-02792-3.

Myocardial microvascular function assessed by CMR first-pass perfusion in patients treated with chemotherapy for gynecologic malignancies.

Yang M, Li Q, Wang D, Ye L, Li K, Lin X Eur Radiol. 2022; 32(10):6850-6858.

PMID: 35579712 DOI: 10.1007/s00330-022-08823-2.

Association Between Left Ventricular Global Function Index and Outcomes in Patients With Dilated Cardiomyopathy.

Liu T, Zhou Z, Bo K, Gao Y, Wang H, Wang R Front Cardiovasc Med. 2021; 8:751907.

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Cardiac MRI Based Left Ventricular Global Function Index: Association with Disease Severity in Patients with ICD for Secondary Prevention.

Schober A, Jungbauer C, Poschenrieder F, Schober A, Hubauer U, Keyser A J Clin Med. 2021; 10(21).

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Left Ventricular Global Function Index and the Impact of its Companion Metric.

Diaz-Navarro R, Kerkhof P Front Cardiovasc Med. 2021; 8:695883.

PMID: 34527709 PMC: 8435684. DOI: 10.3389/fcvm.2021.695883.

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