The Groucho/Transducin-like Enhancer of Split Protein Family in Animal Development

Overview

Journal IUBMB Life

Specialties Biochemistry
Molecular Biology

Date 2015 Jul 15

PMID 26172616

Citations 41

Authors

Megha Agarwal

Pankaj Kumar

Sam J Mathew

Affiliations

Soon will be listed here.

Abstract

Corepressors are proteins that cannot bind DNA directly but repress transcription by interacting with partner proteins. The Groucho/Transducin-Like Enhancer of Split (TLE) are a conserved family of corepressor proteins present in animals ranging from invertebrates such as Drosophila to vertebrates such as mice and humans. Groucho/TLE proteins perform important functions throughout the life span of animals, interacting with several pathways and regulating fundamental processes such as metabolism. However, these proteins have especially crucial functions in animal development, where they are required in multiple tissues in a temporally regulated manner. In this review, we summarize the functions of the Groucho/TLE proteins during animal development, emphasizing on specific tissues where they play essential roles.

Citing Articles

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TLE4 downregulation identified by WGCNA and machine learning algorithm promotes papillary thyroid carcinoma progression via activating JAK/STAT pathway.

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Sox10 Activity and the Timing of Schwann Cell Differentiation Are Controlled by a Tle4-Dependent Negative Feedback Loop.

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PMID: 38791273 PMC: 11120983. DOI: 10.3390/ijms25105234.

A conserved function of corepressors is to nucleate assembly of the transcriptional preinitiation complex.

Leydon A, Downing B, Solano Sanchez J, Loll-Krippleber R, Belliveau N, Rodriguez-Mias R bioRxiv. 2024; .

PMID: 38617365 PMC: 11014602. DOI: 10.1101/2024.04.01.587599.

The Wnt-pathway corepressor TLE3 interacts with the histone methyltransferase KMT1A to inhibit differentiation in Rhabdomyosarcoma.

Kalita B, Sahu S, Bharadwaj A, Panneerselvam L, Martinez-Cebrian G, Agarwal M Oncogene. 2024; 43(7):524-538.

PMID: 38177411 DOI: 10.1038/s41388-023-02911-3.

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