Accelerated Recovery of Endothelium Function After Stent Implantation with the Use of a Novel Systemic Nanoparticle Curcumin

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2015 Jul 14

PMID 26167481

Citations 3

Authors

Qi Lu

Fang Ye

Xiangjun Yang

Qingqing Gu

Peng Wang

Jianhua Zhu

Li Shen

Feirong Gong

Affiliations

Soon will be listed here.

Abstract

Curcumin was reported to exhibit a wide range of pharmacological effects including antioxidant, anti-inflammatory, and antiproliferative activities and significantly prevent smooth muscle cells migration. In the present study, a novel kind of curcumin loaded nanoparticles (Cur-NP) has been prepared and characterized with the aim of inhibiting inflammation formation and accelerating the healing process of the stented arteries. Cur-NP was administrated intravenously after stent implantation twice a week and detailed tissue responses were evaluated. The results demonstrated that intravenous administration of Cur-NP after stent implantation accelerated endothelial cells restoration and endothelium function recovery and may potentially be an effective therapeutic alternative to reduce adverse events for currently available drug eluting stents.

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