Synthesis of 2-Acylphenol and Flavene Derivatives from the Ruthenium-Catalyzed Oxidative C-H Acylation of Phenols with Aldehydes

Overview

Journal European J Org Chem

Specialty Biochemistry

Date 2015 Jul 14

PMID 26167129

Citations 5

Authors

Hanbin Lee

Chae S Yi

Affiliations

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Abstract

The cationic ruthenium hydride complex [(CH)(PCy)(CO)RuH]BF has been found to be an effective catalyst for the oxidative C-H coupling reaction of phenols with aldehydes to give 2-acylphenol compounds. The coupling of phenols with α,β-unsaturated aldehydes selectively gives the flavene derivatives. The catalytic method mediates direct oxidative C-H coupling of phenol and aldehyde substrates without using any metal oxidants or forming wasteful byproducts.

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