Synthesis and Molecular Structure of Novel 2-(alkylthio)-4-chloro--(4,5-dihydro-5-oxo-1-1,2,4-triazol-3-yl)-5-methylbenzenesulfonamides with Potential Anticancer Activity

Overview

Journal Monatsh Chem

Specialty Chemistry

Date 2015 Jul 14

PMID 26166861

Citations 10

Authors

Jaroslaw Slawinski

Beata Zolnowska

Czeslawa Orlewska

Jaroslaw Chojnacki

Affiliations

Soon will be listed here.

Abstract

Abstract: A series of novel 4-chloro--(4,5-dihydro-5-oxo-1-R-1-1,2,4-triazol-3-yl)-5-methyl-2-(R-methylthio)benzenesulfonamide derivatives have been synthesized as potential anticancer agents. The in vitro antitumor activity of some compounds was evaluated in the US National Cancer Institute (NCI) against the NCI-60 cell line panel. The most prominent compound showed remarkable activity against 13 human tumor cell lines representing lung, colon, CNS, melanoma, ovarian, renal, prostate, and breast at low micromolar GI level in the range of 1.9-3.0 μM.

Graphical Abstract:

Citing Articles

Novel 2-alkythio-4-chloro--[imino(heteroaryl)methyl]benzenesulfonamide Derivatives: Synthesis, Molecular Structure, Anticancer Activity and Metabolic Stability.

Zolnowska B, Slawinski J, Belka M, Baczek T, Chojnacki J, Kawiak A Int J Mol Sci. 2023; 24(11).

PMID: 37298719 PMC: 10253812. DOI: 10.3390/ijms24119768.

An In Vitro Antimicrobial, Anticancer and Antioxidant Activity of -[(2-Arylmethylthio)phenylsulfonyl]cinnamamide Derivatives.

Bulakowska A, Slawinski J, Halasa R, Hering A, Gucwa M, Ochocka J Molecules. 2023; 28(7).

PMID: 37049849 PMC: 10096175. DOI: 10.3390/molecules28073087.

New 2-[(4-Amino-6--substituted-1,3,5-triazin-2-yl)methylthio]--(imidazolidin-2-ylidene)-4-chloro-5-methylbenzenesulfonamide Derivatives, Design, Synthesis and Anticancer Evaluation.

Tomorowicz L, Zolnowska B, Szafranski K, Chojnacki J, Konopinski R, Grzybowska E Int J Mol Sci. 2022; 23(13).

PMID: 35806186 PMC: 9267128. DOI: 10.3390/ijms23137178.

-(2-Arylmethylthio-4-Chloro-5-Methylbenzenesulfonyl)amide Derivatives as Potential Antimicrobial Agents-Synthesis and Biological Studies.

Zolnowska B, Slawinski J, Garbacz K, Jarosiewicz M, Kawiak A Int J Mol Sci. 2020; 21(1).

PMID: 31892248 PMC: 6981581. DOI: 10.3390/ijms21010210.

Novel 5-Substituted 2-(Aylmethylthio)-4-chloro-N-(5-aryl-1,2,4-triazin-3-yl)benzenesulfonamides: Synthesis, Molecular Structure, Anticancer Activity, Apoptosis-Inducing Activity and Metabolic Stability.

Zolnowska B, Slawinski J, Pogorzelska A, Szafranski K, Kawiak A, Stasilojc G Molecules. 2016; 21(6).

PMID: 27338337 PMC: 6273912. DOI: 10.3390/molecules21060808.

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